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dc.contributor.author | URIKURA, Itaru | en |
dc.contributor.author | SUGAWARA, Tatsuya | en |
dc.contributor.author | HIRATA, Takashi | en |
dc.contributor.alternative | 菅原, 達也 | ja |
dc.date.accessioned | 2012-06-15T05:32:07Z | - |
dc.date.available | 2012-06-15T05:32:07Z | - |
dc.date.issued | 2011-04 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.uri | http://hdl.handle.net/2433/156504 | - |
dc.description.abstract | Fucoxanthin, a major carotenoid in brown algae, has various beneficial effects. In this study, we evaluated the effect of topical fucoxanthin on UVB-induced skin photoaging in hairless mice. The dorsal skins were treated topically with a 0.001% fucoxanthin solution 2 h each time before UVB irradiation (5 times a week) for 10 weeks. The formation of wrinkles in UVB-irradiated skin treated with vehicle alone significantly increased, as compared with the non-irradiated control. Treatment with fucoxanthin tended to suppress UVB-induced wrinkle formation, but there was no significant difference between wrinkle formation in the control group and the fucoxanthin treatment group. However, topical treatment with fucoxanthin significantly lessened UVB-induced epidermal hypertrophy, VEGF, and MMP-13 expression in the epidermis and thiobarbituric acid reactive substances (TBARS) in the skin. These results indicate that topical treatment with fucoxanthin prevents skin photoaging in UVB-irradiated hairless mice, possibly via antioxidant and antiangiogenic effects. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Japan Society for Bioscience, Biotechnology, and Agrochemistry | en |
dc.rights | (c) 2011 by Japan Society for Bioscience, Biotechnology, and Agrochemistry | en |
dc.subject | fucoxanthin | en |
dc.subject | photoaging | en |
dc.subject | wrinkling | en |
dc.subject | UV-irradiation | en |
dc.subject | angiogenesis | en |
dc.title | Protective Effect of Fucoxanthin against UVB-Induced Skin Photoaging in Hairless Mice | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA10824164 | - |
dc.identifier.jtitle | Bioscience, Biotechnology, and Biochemistry | en |
dc.identifier.volume | 75 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 757 | - |
dc.identifier.epage | 760 | - |
dc.relation.doi | 10.1271/bbb.110040 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 21512228 | - |
dc.relation.url | https://www.jstage.jst.go.jp/article/bbb/75/4/75_110040/_article | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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