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タイトル: | Protective Effect of Fucoxanthin against UVB-Induced Skin Photoaging in Hairless Mice |
著者: | URIKURA, Itaru SUGAWARA, Tatsuya ![]() ![]() ![]() HIRATA, Takashi |
著者名の別形: | 菅原, 達也 |
キーワード: | fucoxanthin photoaging wrinkling UV-irradiation angiogenesis |
発行日: | Apr-2011 |
出版者: | Japan Society for Bioscience, Biotechnology, and Agrochemistry |
誌名: | Bioscience, Biotechnology, and Biochemistry |
巻: | 75 |
号: | 4 |
開始ページ: | 757 |
終了ページ: | 760 |
抄録: | Fucoxanthin, a major carotenoid in brown algae, has various beneficial effects. In this study, we evaluated the effect of topical fucoxanthin on UVB-induced skin photoaging in hairless mice. The dorsal skins were treated topically with a 0.001% fucoxanthin solution 2 h each time before UVB irradiation (5 times a week) for 10 weeks. The formation of wrinkles in UVB-irradiated skin treated with vehicle alone significantly increased, as compared with the non-irradiated control. Treatment with fucoxanthin tended to suppress UVB-induced wrinkle formation, but there was no significant difference between wrinkle formation in the control group and the fucoxanthin treatment group. However, topical treatment with fucoxanthin significantly lessened UVB-induced epidermal hypertrophy, VEGF, and MMP-13 expression in the epidermis and thiobarbituric acid reactive substances (TBARS) in the skin. These results indicate that topical treatment with fucoxanthin prevents skin photoaging in UVB-irradiated hairless mice, possibly via antioxidant and antiangiogenic effects. |
著作権等: | (c) 2011 by Japan Society for Bioscience, Biotechnology, and Agrochemistry |
URI: | http://hdl.handle.net/2433/156504 |
DOI(出版社版): | 10.1271/bbb.110040 |
PubMed ID: | 21512228 |
関連リンク: | https://www.jstage.jst.go.jp/article/bbb/75/4/75_110040/_article |
出現コレクション: | 学術雑誌掲載論文等 |
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