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タイトル: | Degree of freezing does not affect efficacy of frozen gloves for prevention of docetaxel-induced nail toxicity in breast cancer patients. |
著者: | Ishiguro, H ![]() Takashima, S Yoshimura, K Yano, I ![]() Yamamoto, T Niimi, M Yamashiro, H Ueno, T Takeuchi, M Sugie, T Yanagihara, K Toi, M ![]() ![]() Fukushima, M |
著者名の別形: | 石黒, 洋 |
キーワード: | Chemotherapy Docetaxel Frozen glove Nail toxicity Pharmacokinetics |
発行日: | Sep-2012 |
出版者: | Springer Verlag |
誌名: | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer |
巻: | 20 |
号: | 9 |
開始ページ: | 2017 |
終了ページ: | 2024 |
抄録: | [Purpose]:Frozen gloves (FG) are effective in preventing docetaxel-induced nail toxicity (DNT), but uncomfortable. The preventive effect of FG for DNT was compared using a standard (−25 to −30°C) or more comfortable (−10 to −20°C) preparation. [Methods]:Breast cancer patients receiving docetaxel were eligible. Each patient wore an FG (prepared at −10 to −20°C for 90 min) for 60 min without replacement on the right hand. The left hand was protected by standard methods (FG prepared at −25 to −30°C overnight and worn for 90 min with replacement at 45 min). The primary endpoint was DNT occurrence at 5 months. Secondary endpoints included docetaxel exposure [cumulative dose and area under the blood concentration time curve (AUC)] until DNT occurrence and discomfort from FG. The pharmacokinetics of docetaxel was assessed. [Results]:From 23 patients enrolled between December 2006 and June 2010, seven who received docetaxel for less than 5 months were excluded from evaluation. The median accumulated docetaxel dose was 700 mg/m2 (340–1430 mg/m2). Within 5 months of FG use, none developed protocol-defined DNT in either hand. Two patients (13%) developed DNT at 7.2 and 7.3 months, respectively, both at −10 to −20°C. In the control hand (−25 to −30°C), discomfort occurred in 92% of the cycles, compared to 15% in the experimental hand (−10 to −20°C). Five patients (22%) experienced pain at −25 to −30°C, but none did at −10 to −20°C. The degree of docetaxel exposure was not related to DNT occurrence in our study. [Conclusion]:A convenient preparation of FG at −10 to −20°C is almost as effective as a standard preparation at −25 to −30°C, with significantly less discomfort. |
著作権等: | © The Author(s) 2011. This article is published with open access at Springerlink.com |
URI: | http://hdl.handle.net/2433/160053 |
DOI(出版社版): | 10.1007/s00520-011-1308-4 |
PubMed ID: | 22086405 |
出現コレクション: | 学術雑誌掲載論文等 |
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