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|---|---|---|---|---|
| clpt.2011.38.pdf | 1.41 MB | Adobe PDF | View/Open |
| Title: | The use of induced pluripotent stem cells in drug development. |
| Authors: | Inoue, H    https://orcid.org/0000-0003-4736-9537 (unconfirmed)Yamanaka, S |
| Author's alias: | 井上, 治久 山中, 伸弥 |
| Keywords: | iPS cell drug development disease modeling control definition animal model personalized medicine |
| Issue Date: | May-2011 |
| Publisher: | Nature Publishing Group |
| Journal title: | Clinical pharmacology and therapeutics |
| Volume: | 89 |
| Issue: | 5 |
| Start page: | 655 |
| End page: | 661 |
| Abstract: | Induced pluripotent stem cell (iPSC) technology is revolutionizing medical science, allowing the exploration of disease mechanisms and novel therapeutic molecular targets, and offering opportunities for drug discovery and proof-of-concept studies in drug development. This review focuses on the recent advancements in iPSC technology including disease modeling and control setting in its analytical paradigm. We describe how iPSC technology is integrated into existing paradigms of drug development and discuss the potential of iPSC technology in personalized medicine. |
| Rights: | © 2012 American Society for Clinical Pharmacology and Therapeutics この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
| URI: | http://hdl.handle.net/2433/160140 |
| DOI(Published Version): | 10.1038/clpt.2011.38 |
| PubMed ID: | 21430656 |
| Appears in Collections: | Journal Articles |
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