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Title: The use of induced pluripotent stem cells in drug development.
Authors: Inoue, H  kyouindb  KAKEN_id  orcid (unconfirmed)
Yamanaka, S  kyouindb  KAKEN_id
Author's alias: 井上, 治久
山中, 伸弥
Keywords: iPS cell
drug development
disease modeling
control definition
animal model
personalized medicine
Issue Date: May-2011
Publisher: Nature Publishing Group
Journal title: Clinical pharmacology and therapeutics
Volume: 89
Issue: 5
Start page: 655
End page: 661
Abstract: Induced pluripotent stem cell (iPSC) technology is revolutionizing medical science, allowing the exploration of disease mechanisms and novel therapeutic molecular targets, and offering opportunities for drug discovery and proof-of-concept studies in drug development. This review focuses on the recent advancements in iPSC technology including disease modeling and control setting in its analytical paradigm. We describe how iPSC technology is integrated into existing paradigms of drug development and discuss the potential of iPSC technology in personalized medicine.
Rights: © 2012 American Society for Clinical Pharmacology and Therapeutics
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1038/clpt.2011.38
PubMed ID: 21430656
Appears in Collections:Journal Articles

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