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タイトル: | Association of ARMS2 genotype with bilateral involvement of exudative age-related macular degeneration. |
著者: | Tamura, Hiroshi https://orcid.org/0000-0002-7740-2732 (unconfirmed) Tsujikawa, Akitaka Yamashiro, Kenji Akagi-Kurashige, Yumiko Nakata, Isao Nakanishi, Hideo Hayashi, Hisako Ooto, Sotaro Otani, Atsushi Yoshimura, Nagahisa |
著者名の別形: | 田村, 寛 |
キーワード: | age-related macular degeneration second eye genotype ARMS2 |
発行日: | Sep-2012 |
出版者: | Elsevier Inc. |
誌名: | American journal of ophthalmology |
巻: | 154 |
号: | 3 |
開始ページ: | 542 |
終了ページ: | 548.e1 |
抄録: | [Purpose]: To study the association of ARMS2 A69S genotype with the development of exudative age-related macular degeneration (AMD) in the unaffected fellow eye and to estimate the duration until the development of AMD in the second eye. [Design]: Retrospective cohort study. [Methods]: We retrospectively reviewed 326 patients who had exudative AMD in at least 1 eye, genotyping of ARMS2 A69S, and a minimum follow-up of 2 years. Survival analysis and Cox proportional hazard regression analysis were used to examine the association between candidate factors and the duration until the development of AMD in the second eye. [Results]: One hundred nineteen patients (36.5%) had bilateral exudative AMD at the initial visit. A risk allele of ARMS2 A69S was more frequently seen in patients with bilateral AMD (P = .0270) than in those with unilateral AMD. Of the 207 unilateral AMD patients, 23 (11.1%) had AMD in the fellow eye after a mean duration of 56.3 ± 40.4 months. Fellow-eye involvement was associated with ARMS2 A69S genotype (hazard ratio [HR], 2.673; P = .0013), age (HR, 1.102; P = .0005), and smoking history (HR, 0.680; P = .3663). As HRs indicate, correlation of genotype (2.673) was as high as that of 10-year aging (1.10210 = 2.641). Survival analysis revealed that patients with risk homozygous (TT) genotype had second-eye involvement significantly earlier than those with other genotypes (P = .0028). When the observation duration reached 120 months, second-eye involvement had developed in 50%, 6.6%, and 11.2% of the TT, GT, and GG cohorts, respectively. [Conclusion]: ARMS2 A69S genotype is associated with second-eye involvement of exudative AMD and with the period between first- and second-eye involvements. |
著作権等: | © 2012 Elsevier Inc. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/160394 |
DOI(出版社版): | 10.1016/j.ajo.2012.03.042 |
PubMed ID: | 22809783 |
出現コレクション: | 学術雑誌掲載論文等 |
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