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タイトル: | Dclk1 distinguishes between tumor and normal stem cells in the intestine |
著者: | Nakanishi, Yuki Seno, Hiroshi Fukuoka, Ayumi Ueo, Taro Yamaga, Yuichi Maruno, Takahisa Nakanishi, Naoko Kanda, Keitaro Komekado, Hideyuki Kawada, Mayumi Isomura, Akihiro Kawada, Kenji Sakai, Yoshiharu Yanagita, Motoko Kageyama, Ryoichiro https://orcid.org/0000-0002-5985-1120 (unconfirmed) Kawaguchi, Yoshiya Taketo, Makoto M Yonehara, Shin Chiba, Tsutomu |
著者名の別形: | 妹尾, 浩 |
キーワード: | tumor initiating cell cancer stem cell lineage tracing colon cancer Dcamkl1 |
発行日: | 2-Dec-2012 |
出版者: | Nature Publishing Group |
誌名: | Nature Genetics |
巻: | 45 |
号: | 1 |
開始ページ: | 98 |
終了ページ: | 103 |
抄録: | There is great interest in tumor stem cells (TSCs) as potential therapeutic targets; however, cancer therapies targeting TSCs are limited. A drawback is that TSC markers are often shared by normal stem cells (NSCs)1–4; thus, therapies that target these markers may cause severe injury to normal tissues. To identify a potential TSC-specific marker, we focused on doublecortin-like kinase 1 (Dclk1). Dclk1 was reported as a candidate NSC marker in the gut5, 6, but recent reports have implicated it as a marker of differentiated cells (for example, Tuft cells)7, 8. Using lineage-tracing experiments, we show here that Dclk1 does not mark NSCs in the intestine but instead marks TSCs that continuously produce tumor progeny in the polyps of ApcMin/+ mice. Specific ablation of Dclk1-positive TSCs resulted in a marked regression of polyps without apparent damage to the normal intestine. Our data suggest the potential for developing a therapy for colorectal cancer based on targeting Dclk1-positive TSCs. |
記述: | 癌幹細胞を特定するマーカー同定に成功 : 新世代の癌治療法開発に期待.京都大学プレスリリース.2012-12-03. |
著作権等: | © 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 許諾条件により本文は2013-06-02に公開. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/163077 |
DOI(出版社版): | 10.1038/ng.2481 |
PubMed ID: | 23202126 |
関連リンク: | https://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2012/121203_1.htm |
出現コレクション: | 学術雑誌掲載論文等 |
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