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タイトル: Dclk1 distinguishes between tumor and normal stem cells in the intestine
著者: Nakanishi, Yuki
Seno, Hiroshi
Fukuoka, Ayumi
Ueo, Taro
Yamaga, Yuichi
Maruno, Takahisa
Nakanishi, Naoko
Kanda, Keitaro
Komekado, Hideyuki
Kawada, Mayumi
Isomura, Akihiro  KAKEN_id
Kawada, Kenji  kyouindb  KAKEN_id
Sakai, Yoshiharu  kyouindb  KAKEN_id
Yanagita, Motoko
Kageyama, Ryoichiro  kyouindb  KAKEN_id
Kawaguchi, Yoshiya  kyouindb  KAKEN_id
Taketo, Makoto M  kyouindb  KAKEN_id
Yonehara, Shin  kyouindb  KAKEN_id
Chiba, Tsutomu
著者名の別形: 妹尾, 浩
キーワード: tumor initiating cell
cancer stem cell
lineage tracing
colon cancer
Dcamkl1
発行日: 2-Dec-2012
出版者: Nature Publishing Group
誌名: Nature Genetics
抄録: There is great interest in tumor stem cells (TSCs) as potential therapeutic targets; however, cancer therapies targeting TSCs are limited. A drawback is that TSC markers are often shared by normal stem cells (NSCs)1–4; thus, therapies that target these markers may cause severe injury to normal tissues. To identify a potential TSC-specific marker, we focused on doublecortin-like kinase 1 (Dclk1). Dclk1 was reported as a candidate NSC marker in the gut5, 6, but recent reports have implicated it as a marker of differentiated cells (for example, Tuft cells)7, 8. Using lineage-tracing experiments, we show here that Dclk1 does not mark NSCs in the intestine but instead marks TSCs that continuously produce tumor progeny in the polyps of ApcMin/+ mice. Specific ablation of Dclk1-positive TSCs resulted in a marked regression of polyps without apparent damage to the normal intestine. Our data suggest the potential for developing a therapy for colorectal cancer based on targeting Dclk1-positive TSCs.
記述: 癌幹細胞を特定するマーカー同定に成功 : 新世代の癌治療法開発に期待.京都大学プレスリリース.2012-12-03.
著作権等: © 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
許諾条件により本文は2013-06-02に公開.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/163077
DOI(出版社版): 10.1038/ng.2481
関連リンク: http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2012/121203_1.htm
出現コレクション:学術雑誌掲載論文等

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