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dc.contributor.author | Tani-ichi, Shizue | en |
dc.contributor.author | Shimba, Akihiro | en |
dc.contributor.author | Wagatsuma, Keisuke | en |
dc.contributor.author | Miyachi, Hitoshi | en |
dc.contributor.author | Kitano, Satsuki | en |
dc.contributor.author | Imai, Kumiko | en |
dc.contributor.author | Hara, Takahiro | en |
dc.contributor.author | Ikuta, Koichi | en |
dc.contributor.alternative | 谷一, 靖江 | ja |
dc.date.accessioned | 2013-02-25T01:55:20Z | - |
dc.date.available | 2013-02-25T01:55:20Z | - |
dc.date.issued | 2013-01-08 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/2433/170273 | - |
dc.description.abstract | Interleukin (IL)-7 is a cytokine essential for T lymphocyte development and homeostasis. However, little is known about the roles of IL-7 receptor α-chain (IL-7Rα) in late stages of T-cell development. To address this question, we established IL-7Rα-floxed mice and crossed them with CD4-Cre transgenic mice. Resultant IL-7R conditional knockout (IL-7RcKO) mice exhibited marked reduction in CD8 single positive (SP) T cells, regulatory T cells (Tregs), and natural killer T (NKT) cells in thymus. The proportion and proliferation of both mature CD4SP and CD8SP thymocytes were decreased without affecting Runx expression. In addition, expression of the glucocorticoid-induced TNF receptor was reduced in CD4SP and CD8SP thymocytes, and expression of CD5 was decreased in CD8SP thymocytes. IL-7RcKO mice also showed impaired Treg and NKT cell proliferation and inhibition of NKT cell maturation. Bcl-2 expression was reduced in CD4SP and CD8SP thymocytes but not in Tregs and NKT cells, and introduction of a Bcl-2 transgene rescued frequency and CD5 expression of CD8SP thymocytes. Furthermore, IL-7RcKO mice exhibited greatly increased numbers of B cells and, to a lesser extent, γδ T and dendritic cells in thymus. Overall, this study demonstrates that IL-7Rα differentially controls development and maturation of thymocyte subpopulations in late developmental stages and suggests that IL-7R expression on αβ T cells suppresses development of other cell lineages in thymus. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | National Academy of Sciences | en |
dc.rights | ©2013 by the National Academy of Sciences | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.title | Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00786025 | - |
dc.identifier.jtitle | Proceedings of the National Academy of Sciences of the United States of America | en |
dc.identifier.volume | 110 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 612 | - |
dc.identifier.epage | 617 | - |
dc.relation.doi | 10.1073/pnas.1219242110 | - |
dc.textversion | author | - |
dc.identifier.pmid | 23267098 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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