|Title:||Identification and Biological Activities of Bryostatins from Japanese Bryozoan|
YANAGITA, Ryo C.
MURAKAMI, Kazuma https://orcid.org/0000-0003-3152-1784 (unconfirmed)
IRIE, Kazuhiro https://orcid.org/0000-0001-7109-8568 (unconfirmed)
|Author's alias:||入江, 一浩|
|Keywords:||protein kinase C|
|Publisher:||Japan Society for Bioscience, Biotechnology, and Agrochemistry|
|Journal title:||Bioscience, Biotechnology, and Biochemistry|
|Abstract:||Six bryostatins were isolated from Japanese bryozoan by evaluating their binding to the C1B domain of protein kinase Cδ (PKCδ). Structure-activity studies of bryostatins 4, 10, and 14 suggested that the ester group at C20 was not necessary for binding to and activating PKCδ. These bryostatins showed significant anti-tumor-promoting activity in induction tests with the Epstein-Barr virus early antigen.|
|Rights:||© 2012 by Japan Society for Bioscience, Biotechnology, and Agrochemistry|
|Appears in Collections:||Journal Articles|
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