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Title: Identification and Biological Activities of Bryostatins from Japanese Bryozoan
Authors: UENO, Sayo
YANAGITA, Ryo C.
MURAKAMI, Kazuma  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-3152-1784 (unconfirmed)
MURAKAMI, Akira  KAKEN_id
TOKUDA, Harukuni
SUZUKI, Nobutaka
FUJIWARA, Takeshi
IRIE, Kazuhiro  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-7109-8568 (unconfirmed)
Author's alias: 入江, 一浩
Keywords: protein kinase C
bryostatin
Bugula neritina
tumor promotion
Epstein-Barr virus
Issue Date: May-2012
Publisher: Japan Society for Bioscience, Biotechnology, and Agrochemistry
Journal title: Bioscience, Biotechnology, and Biochemistry
Volume: 76
Issue: 5
Start page: 1041
End page: 1043
Abstract: Six bryostatins were isolated from Japanese bryozoan by evaluating their binding to the C1B domain of protein kinase Cδ (PKCδ). Structure-activity studies of bryostatins 4, 10, and 14 suggested that the ester group at C20 was not necessary for binding to and activating PKCδ. These bryostatins showed significant anti-tumor-promoting activity in induction tests with the Epstein-Barr virus early antigen.
Rights: © 2012 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
URI: http://hdl.handle.net/2433/176984
DOI(Published Version): 10.1271/bbb.120026
Related Link: https://www.jstage.jst.go.jp/article/bbb/76/5/76_120026/_article
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