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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| bbb_120026.pdf | 122.65 kB | Adobe PDF | 見る/開く |
| タイトル: | Identification and Biological Activities of Bryostatins from Japanese Bryozoan |
| 著者: | UENO, Sayo YANAGITA, Ryo C. MURAKAMI, Kazuma    https://orcid.org/0000-0003-3152-1784 (unconfirmed)MURAKAMI, Akira TOKUDA, Harukuni SUZUKI, Nobutaka FUJIWARA, Takeshi IRIE, Kazuhiro https://orcid.org/0000-0001-7109-8568 (unconfirmed) |
| 著者名の別形: | 入江, 一浩 |
| キーワード: | protein kinase C bryostatin Bugula neritina tumor promotion Epstein-Barr virus |
| 発行日: | May-2012 |
| 出版者: | Japan Society for Bioscience, Biotechnology, and Agrochemistry |
| 誌名: | Bioscience, Biotechnology, and Biochemistry |
| 巻: | 76 |
| 号: | 5 |
| 開始ページ: | 1041 |
| 終了ページ: | 1043 |
| 抄録: | Six bryostatins were isolated from Japanese bryozoan by evaluating their binding to the C1B domain of protein kinase Cδ (PKCδ). Structure-activity studies of bryostatins 4, 10, and 14 suggested that the ester group at C20 was not necessary for binding to and activating PKCδ. These bryostatins showed significant anti-tumor-promoting activity in induction tests with the Epstein-Barr virus early antigen. |
| 著作権等: | © 2012 by Japan Society for Bioscience, Biotechnology, and Agrochemistry |
| URI: | http://hdl.handle.net/2433/176984 |
| DOI(出版社版): | 10.1271/bbb.120026 |
| PubMed ID: | 22738985 |
| 関連リンク: | https://www.jstage.jst.go.jp/article/bbb/76/5/76_120026/_article |
| 出現コレクション: | 学術雑誌掲載論文等 |
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