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j.imlet.2013.08.005.pdf | 585.43 kB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | Yoshida, Tomoyuki | en |
dc.contributor.author | Suzuki, Saori | en |
dc.contributor.author | Iwasaki, Yuki | en |
dc.contributor.author | Kaneko, Akihisa | en |
dc.contributor.author | Saito, Akatsuki | en |
dc.contributor.author | Enomoto, Yuki | en |
dc.contributor.author | Higashino, Atsunori | en |
dc.contributor.author | Watanabe, Akino | en |
dc.contributor.author | Suzuki, Juri | en |
dc.contributor.author | Inoue, Kenichi | en |
dc.contributor.author | Kuroda, Teiko | en |
dc.contributor.author | Takada, Masahiko | en |
dc.contributor.author | Ito, Ryoji | en |
dc.contributor.author | Ito, Mamoru | en |
dc.contributor.author | Akari, Hirofumi | en |
dc.contributor.alternative | 吉田, 友教 | ja |
dc.contributor.alternative | 明里, 宏文 | ja |
dc.date.accessioned | 2013-10-18T01:46:21Z | - |
dc.date.available | 2013-10-18T01:46:21Z | - |
dc.date.issued | 2013-07 | - |
dc.identifier.issn | 0165-2478 | - |
dc.identifier.uri | http://hdl.handle.net/2433/179281 | - |
dc.description.abstract | In order to directly demonstrate the roles of CD8(+) T lymphocytes in non-human primates, in vivo depletion of the CD8(+) T cells by administration of a CD8-specific monoclonal antibody (mAb) is one of the crucial techniques. Recently, the common marmoset (Callithrix jacchus), which is classified as a New World monkey, has been shown useful as an experimental animal model for various human diseases such as multiple sclerosis, Parkinson's disease and a number of infectious diseases. Here we show that an anti-marmoset CD8 mAb 6F10, which we have recently established, efficiently depletes the marmoset CD8(+) T lymphocytes in vivo, i.e., the administration of 6F10 induces drastic and specific reduction in the ratio of the CD8(+) T cell subset for at least three weeks or longer. Our finding will help understand the pivotal role of CD8(+) T cells in vivo in the control of human diseases. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | en |
dc.rights | © 2013 Elsevier B.V. | en |
dc.rights | この論文は著者最終稿です。内容が印刷版と異なることがありますので、引用の際には出版社版をご確認ご利用ください。This is the Accepted Author Manuscript. Please cite only the published version. | ja |
dc.subject | Monoclonal antibody | en |
dc.subject | CD8 T lymphocyte | en |
dc.subject | Common marmoset | en |
dc.subject | n vivo depletion | en |
dc.title | Efficient in vivo depletion of CD8(+) T lymphocytes in common marmosets by novel CD8 monoclonal antibody administration. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00231960 | - |
dc.identifier.jtitle | Immunology letters | en |
dc.identifier.volume | 154 | - |
dc.identifier.issue | 1-2 | - |
dc.identifier.spage | 12 | - |
dc.identifier.epage | 17 | - |
dc.relation.doi | 10.1016/j.imlet.2013.08.005 | - |
dc.textversion | author | - |
dc.identifier.pmid | 23969290 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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