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dc.contributor.authorYoshida, Tomoyukija
dc.contributor.authorSuzuki, Saorija
dc.contributor.authorIwasaki, Yukija
dc.contributor.authorKaneko, Akihisaja
dc.contributor.authorSaito, Akatsukija
dc.contributor.authorEnomoto, Yukija
dc.contributor.authorHigashino, Atsunorija
dc.contributor.authorWatanabe, Akinoja
dc.contributor.authorSuzuki, Jurija
dc.contributor.authorInoue, Kenichija
dc.contributor.authorKuroda, Teikoja
dc.contributor.authorTakada, Masahikoja
dc.contributor.authorIto, Ryojija
dc.contributor.authorIto, Mamoruja
dc.contributor.authorAkari, Hirofumija
dc.contributor.alternative吉田, 友教ja
dc.contributor.alternative明里, 宏文ja
dc.description.abstractIn order to directly demonstrate the roles of CD8(+) T lymphocytes in non-human primates, in vivo depletion of the CD8(+) T cells by administration of a CD8-specific monoclonal antibody (mAb) is one of the crucial techniques. Recently, the common marmoset (Callithrix jacchus), which is classified as a New World monkey, has been shown useful as an experimental animal model for various human diseases such as multiple sclerosis, Parkinson's disease and a number of infectious diseases. Here we show that an anti-marmoset CD8 mAb 6F10, which we have recently established, efficiently depletes the marmoset CD8(+) T lymphocytes in vivo, i.e., the administration of 6F10 induces drastic and specific reduction in the ratio of the CD8(+) T cell subset for at least three weeks or longer. Our finding will help understand the pivotal role of CD8(+) T cells in vivo in the control of human diseases.ja
dc.publisherElsevier B.V.ja
dc.rights© 2013 Elsevier B.V.ja
dc.rightsこの論文は著者最終稿です。内容が印刷版と異なることがありますので、引用の際には出版社版をご確認ご利用ください。This is the Accepted Author Manuscript. Please cite only the published version.ja
dc.subjectMonoclonal antibodyja
dc.subjectCD8 T lymphocyteja
dc.subjectCommon marmosetja
dc.subjectn vivo depletionja
dc.titleEfficient in vivo depletion of CD8(+) T lymphocytes in common marmosets by novel CD8 monoclonal antibody administration.ja
dc.type.niitypeJournal Articleja
dc.identifier.jtitleImmunology lettersja
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