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タイトル: | Efficient in vivo depletion of CD8(+) T lymphocytes in common marmosets by novel CD8 monoclonal antibody administration. |
著者: | Yoshida, Tomoyuki Suzuki, Saori Iwasaki, Yuki Kaneko, Akihisa Saito, Akatsuki Enomoto, Yuki Higashino, Atsunori https://orcid.org/0000-0002-0817-967X (unconfirmed) Watanabe, Akino Suzuki, Juri Inoue, Kenichi https://orcid.org/0000-0002-5683-5280 (unconfirmed) Kuroda, Teiko Takada, Masahiko https://orcid.org/0000-0003-0774-2333 (unconfirmed) Ito, Ryoji Ito, Mamoru Akari, Hirofumi https://orcid.org/0000-0003-2166-6015 (unconfirmed) |
著者名の別形: | 吉田, 友教 明里, 宏文 |
キーワード: | Monoclonal antibody CD8 T lymphocyte Common marmoset n vivo depletion |
発行日: | Jul-2013 |
出版者: | Elsevier B.V. |
誌名: | Immunology letters |
巻: | 154 |
号: | 1-2 |
開始ページ: | 12 |
終了ページ: | 17 |
抄録: | In order to directly demonstrate the roles of CD8(+) T lymphocytes in non-human primates, in vivo depletion of the CD8(+) T cells by administration of a CD8-specific monoclonal antibody (mAb) is one of the crucial techniques. Recently, the common marmoset (Callithrix jacchus), which is classified as a New World monkey, has been shown useful as an experimental animal model for various human diseases such as multiple sclerosis, Parkinson's disease and a number of infectious diseases. Here we show that an anti-marmoset CD8 mAb 6F10, which we have recently established, efficiently depletes the marmoset CD8(+) T lymphocytes in vivo, i.e., the administration of 6F10 induces drastic and specific reduction in the ratio of the CD8(+) T cell subset for at least three weeks or longer. Our finding will help understand the pivotal role of CD8(+) T cells in vivo in the control of human diseases. |
著作権等: | © 2013 Elsevier B.V. この論文は著者最終稿です。内容が印刷版と異なることがありますので、引用の際には出版社版をご確認ご利用ください。This is the Accepted Author Manuscript. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/179281 |
DOI(出版社版): | 10.1016/j.imlet.2013.08.005 |
PubMed ID: | 23969290 |
出現コレクション: | 学術雑誌掲載論文等 |
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