Downloads: 268

Files in This Item:
File Description SizeFormat 
j.devcel.2013.10.024.pdf17.47 MBAdobe PDFView/Open
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHattori, Yukakoen
dc.contributor.authorUsui, Tadaoen
dc.contributor.authorSatoh, Daisukeen
dc.contributor.authorMoriyama, Sanefumien
dc.contributor.authorShimono, Koheien
dc.contributor.authorItoh, Takehikoen
dc.contributor.authorShirahige, Katsuhikoen
dc.contributor.authorUemura, Tadashien
dc.contributor.alternative服部, 佑佳子ja
dc.contributor.alternative碓井, 理夫ja
dc.contributor.alternative佐藤, 大祐ja
dc.contributor.alternative森山, 翔文ja
dc.contributor.alternative下野, 耕平ja
dc.contributor.alternative伊藤, 武彦ja
dc.contributor.alternative白髭, 克彦ja
dc.contributor.alternative上村, 匡ja
dc.date.accessioned2013-12-02T01:09:09Z-
dc.date.available2013-12-02T01:09:09Z-
dc.date.issued2013-12-09-
dc.identifier.issn1534-5807-
dc.identifier.urihttp://hdl.handle.net/2433/179534-
dc.description神経細胞の個性を生み出すしくみの解明 -サブタイプ特異的な形づくりの遺伝子プログラム-. 京都大学プレスリリース. 2013-11-28.ja
dc.description.abstractThe transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of isolated these neurons. Their profiles were similarly enriched in cell-type-specific enhancers of genes implicated in neural development. We identified a total of 429 target genes, of which 56 were common to Ab and Kn; these targets included genes necessary to shape dendritic arbors in either or both of the two sensory subtypes. Furthermore, a common target gene, encoding the cell adhesion molecule Ten-m, was expressed more strongly in class I than IV, and this differential was critical to the class-selective directional control of dendritic branch sprouting or extension. Our analyses illustrate how differentiating neurons employ distinct and shared repertoires of gene expression to produce class-selective morphological traits.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherElsevier B.V.en
dc.rights© 2013 Elsevier B.V.en
dc.rightsThis is not the published version. Please cite only the published version.en
dc.rightsこの論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。ja
dc.titleSensory-Neuron Subtype-Specific Transcriptional Programs Controlling Dendrite Morphogenesis: Genome-wide Analysis of Abrupt and Knot/Collieren
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.ncidAA11561311-
dc.identifier.jtitleDevelopmental Cellen
dc.identifier.volume27-
dc.identifier.issue5-
dc.identifier.spage530-
dc.identifier.epage544-
dc.relation.doi10.1016/j.devcel.2013.10.024-
dc.textversionauthor-
dc.identifier.pmid24290980-
dc.relation.urlhttps://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2013_1/131128_1.htm-
dcterms.accessRightsopen access-
Appears in Collections:Journal Articles

Show simple item record

Export to RefWorks


Export Format: 


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.