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j.devcel.2013.10.024.pdf | 17.47 MB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | Hattori, Yukako | en |
dc.contributor.author | Usui, Tadao | en |
dc.contributor.author | Satoh, Daisuke | en |
dc.contributor.author | Moriyama, Sanefumi | en |
dc.contributor.author | Shimono, Kohei | en |
dc.contributor.author | Itoh, Takehiko | en |
dc.contributor.author | Shirahige, Katsuhiko | en |
dc.contributor.author | Uemura, Tadashi | en |
dc.contributor.alternative | 服部, 佑佳子 | ja |
dc.contributor.alternative | 碓井, 理夫 | ja |
dc.contributor.alternative | 佐藤, 大祐 | ja |
dc.contributor.alternative | 森山, 翔文 | ja |
dc.contributor.alternative | 下野, 耕平 | ja |
dc.contributor.alternative | 伊藤, 武彦 | ja |
dc.contributor.alternative | 白髭, 克彦 | ja |
dc.contributor.alternative | 上村, 匡 | ja |
dc.date.accessioned | 2013-12-02T01:09:09Z | - |
dc.date.available | 2013-12-02T01:09:09Z | - |
dc.date.issued | 2013-12-09 | - |
dc.identifier.issn | 1534-5807 | - |
dc.identifier.uri | http://hdl.handle.net/2433/179534 | - |
dc.description | 神経細胞の個性を生み出すしくみの解明 -サブタイプ特異的な形づくりの遺伝子プログラム-. 京都大学プレスリリース. 2013-11-28. | ja |
dc.description.abstract | The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of isolated these neurons. Their profiles were similarly enriched in cell-type-specific enhancers of genes implicated in neural development. We identified a total of 429 target genes, of which 56 were common to Ab and Kn; these targets included genes necessary to shape dendritic arbors in either or both of the two sensory subtypes. Furthermore, a common target gene, encoding the cell adhesion molecule Ten-m, was expressed more strongly in class I than IV, and this differential was critical to the class-selective directional control of dendritic branch sprouting or extension. Our analyses illustrate how differentiating neurons employ distinct and shared repertoires of gene expression to produce class-selective morphological traits. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | en |
dc.rights | © 2013 Elsevier B.V. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.title | Sensory-Neuron Subtype-Specific Transcriptional Programs Controlling Dendrite Morphogenesis: Genome-wide Analysis of Abrupt and Knot/Collier | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA11561311 | - |
dc.identifier.jtitle | Developmental Cell | en |
dc.identifier.volume | 27 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 530 | - |
dc.identifier.epage | 544 | - |
dc.relation.doi | 10.1016/j.devcel.2013.10.024 | - |
dc.textversion | author | - |
dc.identifier.pmid | 24290980 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2013_1/131128_1.htm | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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