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ファイル | 記述 | サイズ | フォーマット | |
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j.devcel.2013.10.024.pdf | 17.47 MB | Adobe PDF | 見る/開く |
タイトル: | Sensory-Neuron Subtype-Specific Transcriptional Programs Controlling Dendrite Morphogenesis: Genome-wide Analysis of Abrupt and Knot/Collier |
著者: | Hattori, Yukako https://orcid.org/0000-0001-5977-8501 (unconfirmed) Usui, Tadao https://orcid.org/0000-0002-0507-1495 (unconfirmed) Satoh, Daisuke Moriyama, Sanefumi Shimono, Kohei Itoh, Takehiko Shirahige, Katsuhiko Uemura, Tadashi https://orcid.org/0000-0001-7204-3606 (unconfirmed) |
著者名の別形: | 服部, 佑佳子 碓井, 理夫 佐藤, 大祐 森山, 翔文 下野, 耕平 伊藤, 武彦 白髭, 克彦 上村, 匡 |
発行日: | 9-Dec-2013 |
出版者: | Elsevier B.V. |
誌名: | Developmental Cell |
巻: | 27 |
号: | 5 |
開始ページ: | 530 |
終了ページ: | 544 |
抄録: | The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of isolated these neurons. Their profiles were similarly enriched in cell-type-specific enhancers of genes implicated in neural development. We identified a total of 429 target genes, of which 56 were common to Ab and Kn; these targets included genes necessary to shape dendritic arbors in either or both of the two sensory subtypes. Furthermore, a common target gene, encoding the cell adhesion molecule Ten-m, was expressed more strongly in class I than IV, and this differential was critical to the class-selective directional control of dendritic branch sprouting or extension. Our analyses illustrate how differentiating neurons employ distinct and shared repertoires of gene expression to produce class-selective morphological traits. |
記述: | 神経細胞の個性を生み出すしくみの解明 -サブタイプ特異的な形づくりの遺伝子プログラム-. 京都大学プレスリリース. 2013-11-28. |
著作権等: | © 2013 Elsevier B.V. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/179534 |
DOI(出版社版): | 10.1016/j.devcel.2013.10.024 |
PubMed ID: | 24290980 |
関連リンク: | https://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2013_1/131128_1.htm |
出現コレクション: | 学術雑誌掲載論文等 |
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