チベット高地における老化と酸化ストレス

Abstract

Oxidative stress is hypothesized to be one of the main causes of senescence. Although there are several environmental factors which may contribute to the oxidative stress at high altitude, little is known about the association between oxidative stress and senescence in the community-dwelling elderly at high altitude. We examined reactive oxygen species (ROS) and comprehensive geriatric functions among community-dwelling elderly subjects aged 60 years or more in Tibetan plateau. As a marker of ROS, the levels of reactive oxygen metabolites (ROM) were measured using the d-ROM test (Diacron, Parma, Italy). Stepwise multiple regression analysis showed that the Tibetan, female, hemoglobin and oxygen saturation were independent associated factors of increasing d-ROM level. The high levels of ROM were significantly associated with dependence of basic ADL after adjustment for age, sex and ethnicity. Further studies are needed to show the association among adaptation pattern to high altitude, oxidative stress and senescence.