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タイトル: | p54nrb/NonO and PSF promote U snRNA nuclear export by accelerating its export complex assembly. |
著者: | Izumi, Hiroto McCloskey, Asako Shinmyozu, Kaori Ohno, Mutsuhito ![]() |
著者名の別形: | 大野, 睦人 |
発行日: | Apr-2014 |
出版者: | Oxford University Press |
誌名: | Nucleic acids research |
巻: | 42 |
号: | 6 |
開始ページ: | 3998 |
終了ページ: | 4007 |
抄録: | The assembly of spliceosomal U snRNPs in metazoans requires nuclear export of U snRNA precursors. Four factors, nuclear cap-binding complex (CBC), phosphorylated adaptor for RNA export (PHAX), the export receptor CRM1 and RanGTP, gather at the m(7)G-cap-proximal region and form the U snRNA export complex. Here we show that the multifunctional RNA-binding proteins p54nrb/NonO and PSF are U snRNA export stimulatory factors. These proteins, likely as a heterodimer, accelerate the recruitment of PHAX, and subsequently CRM1 and Ran onto the RNA substrates in vitro, which mediates efficient U snRNA export in vivo. Our results reveal a new layer of regulation for U snRNA export and, hence, spliceosomal U snRNP biogenesis. |
著作権等: | © The Author(s) 2014. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
URI: | http://hdl.handle.net/2433/187373 |
DOI(出版社版): | 10.1093/nar/gkt1365 |
PubMed ID: | 24413662 |
出現コレクション: | 学術雑誌掲載論文等 |
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