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dc.contributor.author | Kinashi, Yuko | en |
dc.contributor.author | Okumura, Kakuji | en |
dc.contributor.author | Kubota, Yoshihisa | en |
dc.contributor.author | Kitajima, Erika | en |
dc.contributor.author | Okayasu, Ryuichi | en |
dc.contributor.author | Ono, Koji | en |
dc.contributor.author | Takahashi, Sentaro | en |
dc.contributor.alternative | 木梨, 友子 | ja |
dc.date.accessioned | 2014-07-07T04:17:19Z | - |
dc.date.available | 2014-07-07T04:17:19Z | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 0969-8043 | - |
dc.identifier.uri | http://hdl.handle.net/2433/188913 | - |
dc.description.abstract | [Background]It is generally said that low LET radiation produce high dose-rate effect, on the other hand, no significant dose rate effect is observed in high LET radiation. Although high LET radiations are produced in BNCT, little is known about dose-rate effect of BNCT. [Materials and methods]T98G cells, which were tumor cells, were irradiated by neutron mixed beam with BPA. As normal tissue derived cells, Chinese hamster ovary (CHO-K1) cells and DNA double strand breaks (DNA-DSBs) repair deficient cells, xrs5 cells were irradiated by the neutrons (not including BPA). To DNA-DSBs analysis, T98G cells were stained immunochemically with 53BP1 antibody. The number of DNA-DSBs was determined by counting 53BP1 foci. [Results]There was no dose-rate effect in xrs5 cells. D0 difference between 4 cGy/min and 20 cGy/min irradiation were 0.5 and 5.9 at the neutron and gamma-ray irradiation for CHO-K1, and 0.3 at the neutron for T98G cells. D0 difference between 20 cGy/min and 80 cGy/min irradiation for T98G cells were 1.2 and 0.6 at neutron irradiation plus BPA and gamma-ray. The differences between neutron irradiations at the dose rate in T98G cells were supported by not only the cell viability but also 53BP1 foci assay at 24 h following irradiation to monitor DNA-DSBs. [Conclusion]Dose-rate effect of BNCT when T98G cells include 20 ppm BPA was greater than that of gamma-ray irradiation. Moreover, Dose-rate effect of the neutron beam when CHO-K1 cells did not include BPA was less than that of gamma-ray irradiation These present results may suggest the importance of dose-rate effect for more efficient BNCT and the side effect reduction. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ltd. | en |
dc.rights | © 2013 Elsevier Ltd. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | Dose-rate effect | en |
dc.subject | BNCT | en |
dc.subject | DNA-DSBs | en |
dc.subject | Glioma | en |
dc.title | Dose-rate effect was observed in T98G glioma cells following BNCT. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA10874887 | - |
dc.identifier.jtitle | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine | en |
dc.identifier.volume | 88 | - |
dc.identifier.spage | 81 | - |
dc.identifier.epage | 85 | - |
dc.relation.doi | 10.1016/j.apradiso.2013.11.117 | - |
dc.textversion | author | - |
dc.identifier.pmid | 24360864 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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