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Title: Photothermal ablation of tumor cells using a single-walled carbon nanotube-peptide composite.
Authors: Hashida, Yasuhiko
Tanaka, Hironori
Zhou, Shuwen
Kawakami, Shigeru
Yamashita, Fumiyoshi  kyouindb  KAKEN_id  orcid (unconfirmed)
Murakami, Tatsuya
Umeyama, Tomokazu  kyouindb  KAKEN_id  orcid (unconfirmed)
Imahori, Hiroshi  kyouindb  KAKEN_id
Hashida, Mitsuru  kyouindb  KAKEN_id
Author's alias: 橋田, 泰彦
川上, 茂
橋田, 充
Keywords: Single-walled carbon nanotube
Single-walled carbon nanotube–peptide composite
Near-infrared laser irradiation
Tumor ablation
Photothermal cancer therapy
Aqueous dispersibility
Issue Date: 10-Jan-2014
Publisher: Elsevier B.V.
Journal title: Journal of controlled release
Volume: 173
Start page: 59
End page: 66
Abstract: Single-walled carbon nanotubes (SWCNTs) are known to have great potential for biomedical applications such as photothermal ablation of tumor cells in combination with near-infrared (NIR) irradiation. In this study, the photothermal activity of a novel SWCNTs composite with a designed peptide having a repeated structure of H-(-Lys-Phe-Lys-Ala-)7-OH [(KFKA)7] against tumor cells was evaluated in vitro and in vivo. The SWCNT-(KFKA)7 composite demonstrated high aqueous dispersibility that enabled SWCNTs to be used in tumor ablation. The NIR irradiation of SWCNT-(KFKA)7 solution resulted in a rapid temperature increase dependent on the SWCNTs concentration up to 50μg/ml. Three minutes of NIR irradiation of a colon 26 or HepG2 cell culture incubated with SWCNT-(KFKA)7 resulted in remarkable cell damage, while that by single treatment with SWCNT-(KFKA)7 or NIR irradiation alone was moderate. The intratumoral injection of SWCNT-(KFKA)7 solution followed by NIR irradiation resulted in a rapid increase of the temperature to 43°C in the subcutaneously inoculated colon 26 tumor based on thermographic observation and remarkable suppression of tumor growth compared with treatment with only SWCNT-(KFKA)7 injection alone or NIR irradiation alone. These results suggest the a great potential of an SWCNT-peptide composite for use in photothermal cancer therapy.
Rights: © 2013 Elsevier B.V.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1016/j.jconrel.2013.10.039
PubMed ID: 24211651
Appears in Collections:Journal Articles

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