Downloads: 601

Files in This Item:
File Description SizeFormat 
c3md00177f.pdf2.02 MBAdobe PDFView/Open
Full metadata record
DC FieldValueLanguage
dc.contributor.authorWatanabe, Mizukien
dc.contributor.authorUesugi, Motonarien
dc.contributor.alternative上杉, 志成ja
dc.date.accessioned2015-01-15T02:16:21Z-
dc.date.available2015-01-15T02:16:21Z-
dc.date.issued2013-08-19-
dc.identifier.issn2040-2503-
dc.identifier.urihttp://hdl.handle.net/2433/192998-
dc.description.abstractSterol regulatory element-binding proteins (SREBPs) are transcriptional factors that control lipid and cholesterol metabolism. Activation of SREBPs in response to a decrease in cellular sterols results in acceleration of the synthesis of fatty acids, triglycerides, and cholesterol. Aberrant SREBP activity has been linked to metabolic disease states, such as obesity, fatty liver, insulin resistance, hyperlipidemia, and atherosclerosis. Thus, inhibition of SREBP activation is a potential therapeutic approach to treating metabolic disorders. This review focuses on direct or indirect small-molecule inhibitors of SREBP activation.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherRoyal Society of Chemistryen
dc.rights© The Royal Society of Chemistry 2013en
dc.rightsThis is not the published version. Please cite only the published version.en
dc.rightsこの論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。ja
dc.titleSmall-molecule inhibitors of SREBP activation – potential for new treatment of metabolic disordersen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleMedChemCommen
dc.identifier.volume4-
dc.identifier.issue11-
dc.identifier.spage1422-
dc.identifier.epage1433-
dc.relation.doi10.1039/c3md00177f-
dc.textversionauthor-
dcterms.accessRightsopen access-
Appears in Collections:Journal Articles

Show simple item record

Export to RefWorks


Export Format: 


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.