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Title: Small-molecule inhibitors of SREBP activation – potential for new treatment of metabolic disorders
Authors: Watanabe, Mizuki
Uesugi, Motonari
Author's alias: 上杉, 志成
Issue Date: 19-Aug-2013
Publisher: Royal Society of Chemistry
Journal title: MedChemComm
Volume: 4
Issue: 11
Start page: 1422
End page: 1433
Abstract: Sterol regulatory element-binding proteins (SREBPs) are transcriptional factors that control lipid and cholesterol metabolism. Activation of SREBPs in response to a decrease in cellular sterols results in acceleration of the synthesis of fatty acids, triglycerides, and cholesterol. Aberrant SREBP activity has been linked to metabolic disease states, such as obesity, fatty liver, insulin resistance, hyperlipidemia, and atherosclerosis. Thus, inhibition of SREBP activation is a potential therapeutic approach to treating metabolic disorders. This review focuses on direct or indirect small-molecule inhibitors of SREBP activation.
Rights: © The Royal Society of Chemistry 2013
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1039/c3md00177f
Appears in Collections:Journal Articles

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