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Title: Quantitative Susceptibility Mapping at 3 T and 1.5 T: Evaluation of Consistency and Reproducibility.
Authors: Hinoda, Takuya  kyouindb  KAKEN_id  orcid (unconfirmed)
Fushimi, Yasutaka  kyouindb  KAKEN_id  orcid (unconfirmed)
Okada, Tomohisa  kyouindb  KAKEN_id  orcid (unconfirmed)
Fujimoto, Koji  kyouindb  KAKEN_id  orcid (unconfirmed)
Liu, Chunlei
Yamamoto, Akira  kyouindb  KAKEN_id  orcid (unconfirmed)
Okada, Tsutomu  kyouindb  KAKEN_id
Kido, Aki
Togashi, Kaori  kyouindb  KAKEN_id
Author's alias: 日野田, 卓也
伏見, 育崇
Keywords: magnetic resonance imaging
Issue Date: 18-Apr-2015
Publisher: Wolters Kluwer Health, Inc
Journal title: Investigative radiology
Volume: 50
Issue: 8
Start page: 522
End page: 530
Abstract: [Objectives]: The aim of this study was to assess the consistency and reproducibility of quantitative susceptibility mapping (QSM) at 3-T and 1.5-T magnetic resonance (MR) scanners. [Materials and Methods]: This study was approved by institutional ethics committee, and written informed consent was obtained. Twenty-two healthy volunteers underwent 2 examinations on different days. Each examination consisted of MR imaging on both 3-T and 1.5-T MR scanners. The data from both scanners and examination days were obtained, and QSM was calculated with STI Suite using 2 different algorithms-harmonic phase removal using laplacian operator (HARPERELLA) and a sophisticated harmonic artifact reduction for phase data (SHARP) method with a variable radius of the spherical kernel at the brain boundary (V-SHARP). We evaluated consistency of QSM between 3 T and 1.5 T and the reproducibility between the first and second examinations using 2-phase processing methods (HARPERELLA and V-SHARP). [Results]: Susceptibility values of regions of interests at 3 T were highly correlated with those at 1.5 T with good agreement (HARPERELLA, R2 = 0.838; V-SHARP, R2 = 0.898) (average difference, +/-1.96 SD; HARPERELLA, -0.012 +/- 0.046; V-SHARP, -0.002 +/- 0.034). Reproducibility analysis demonstrated excellent correlation between the first and second examination at both 3 T and 1.5 T for both algorithms (HARPERELLA at 3 T, R2 = 0.921; 1.5 T, R2 = 0.891; V-SHARP at 3 T, R2 = 0.937; 1.5 T, R2 = 0.926). Bland-Altman analysis showed excellent reproducibility for HARPERELLA (3 T, -0.003 +/- 0.032; 1.5 T, -0.003 +/- 0.038) and V-SHARP (3 T, -0.003 +/- 0.027; 1.5 T, -0.003 +/- 0.029). Susceptibility values of these 2 algorithms were highly correlated with good agreement (3T, R2 = 0.961; 1.5 T, R2 = 0.931) (3 T, 0.009 +/- 0.023; 1.5 T, -0.003 +/- 0.049). [Conclusions]: Quantitative susceptibility mapping with HARPERELLA and V-SHARP demonstrated good reproducibility at 3 T and 1.5 T, and QSM with V-SHARP demonstrated good consistency at 3 T and 1.5 T.
Rights: © 2015 Wolters Kluwer Health. This is a non-final version of an article published in final form in Investigative Radiology: Post Author Corrections: April 18, 2015 doi: 10.1097/RLI.0000000000000159.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1097/RLI.0000000000000159
PubMed ID: 25900085
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