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タイトル: | Adaptive expression of uncoupling protein 1 in the carp liver and kidney in response to changes in ambient temperature. |
著者: | Murakami, Masaru Ohi, Masahiro Ishikawa, Shoko Shirai, Mitsuyuki Horiguchi, Hiroki Nishino, Yoshii Funaba, Masayuki https://orcid.org/0000-0002-4303-6682 (unconfirmed) |
著者名の別形: | 舟場, 正幸 |
キーワード: | UCP1 PPAR PGC-1 RXR Ambient temperature Carps |
発行日: | 10-Apr-2015 |
出版者: | Elsevier Inc. |
誌名: | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology |
巻: | 185 |
開始ページ: | 142 |
終了ページ: | 149 |
抄録: | The expression of uncoupling protein (UCP1) is up-regulated in mammalian brown adipocytes during cold exposure. However, a previous study revealed that UCP1 was highly expressed in the liver of common carps, and that the hepatic expression of UCP1 was down-regulated during cold exposure. The present study examined the effects of temperature on the recovery of UCP1 expression levels and the expression of genes involved in UCP1 transcription in the livers and kidneys of common carps. The hepatic and renal expressions of UCP1 were decreased by acclimation from 22 °C to 8 °C, and a subsequent increase in the water temperature from 8 °C to 28 °C recovered the renal, but not hepatic expression of UCP1. Changes in the expression of peroxisome proliferator-activator receptor (PPAR) γ, retinoid X receptor (RXR) α and PPARγ co-activator (PGC)-1α, genes that are involved in the expression of UCP1 in mammals, with ambient temperature indicated that the expressions of PPARγ and RXRα, but not expression of PGC-1α was decreased in response to cold exposure; the hepatic and renal expressions of PPARγ and RXRα recovered to basal levels with the cessation of cold exposure, although this was not complete for hepatic expression of PPARγ. The results of the present study indicate that a unique regulatory mechanism is responsible for the hepatic and renal expressions of carp UCP1 during cold exposure and subsequent reacclimation, and is distinct from that in murine brown adipocytes. |
著作権等: | © 2015 Elsevier Inc. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/. NOTICE: this is the author's version of a work that was accepted for publication in [Comparative biochemistry and physiology. Part A, Molecular & integrative physiology]. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in [Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, Volume 185, Pages 142–149], doi:10.1016/j.cbpa.2015.04.003. 許諾条件により本文ファイルは2016-04-10に公開. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/198737 |
DOI(出版社版): | 10.1016/j.cbpa.2015.04.003 |
PubMed ID: | 25865906 |
出現コレクション: | 学術雑誌掲載論文等 |
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