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dc.contributor.author | Harada, Yuka | en |
dc.contributor.author | Chihara, Yuichi | en |
dc.contributor.author | Azuma, Masanori | en |
dc.contributor.author | Murase, Kimihiko | en |
dc.contributor.author | Toyama, Yoshiro | en |
dc.contributor.author | Yoshimura, Chikara | en |
dc.contributor.author | Oga, Toru | en |
dc.contributor.author | Nakamura, Hiroshi | en |
dc.contributor.author | Mishima, Michiaki | en |
dc.contributor.author | Chin, Kazuo | en |
dc.contributor.author | Japan Respiratory Failure Group | en |
dc.contributor.alternative | 陳, 和夫 | ja |
dc.date.accessioned | 2015-10-09T06:23:18Z | - |
dc.date.available | 2015-10-09T06:23:18Z | - |
dc.date.issued | 2014-09-10 | - |
dc.identifier.issn | 1323-7799 | - |
dc.identifier.uri | http://hdl.handle.net/2433/200266 | - |
dc.description.abstract | [Background and objective]Obesity hypoventilation syndrome (OHS) prevalence was previously estimated at 9% in patients with obstructive sleep apnoea (OSA) in Japan. However, the definition of OSA in that study was based on an apnoea-hypopnoea index (AHI) of ≥ 20/h rather than ≥ 5/h. Therefore, the prevalence of OHS in OSA was not measured in the same way as for Western countries. Our study objectives were to investigate the characteristics of Japanese patients with OHS. [Methods]Nine hundred eighty-one consecutive patients investigated for suspected OSA were enrolled. At least 90% of them were from urban areas, including 162 with obese OSA (body mass index (BMI) ≥ 30 kg/m2 and AHI ≥ 5/h). [Results]The prevalence of OHS (BMI 36.7 ± 4.9 kg/m2) in OSA and that in obese OSA were 2.3% and 12.3%, respectively. Multiple regression analysis revealed that independent of age and BMI, arterial oxygen pressure (contribution rate (R2) = 7.7%), 4% oxygen desaturation index (R2 = 8.9%), carbon monoxide diffusing capacity/alveolar volume (R2 = 8.3%), haemoglobin concentration (R2 = 4.9%) and waist circumference (R2 = 4.9%) were independently associated with arterial carbon dioxide pressure. After 12.3 ± 4.6 months of CPAP treatment, more than 60% of OHS patients no longer had hypercapnia. [Conclusions]The prevalence of OHS in OSA in Japan was 2.3%. The mean BMI of patients with OHS in Japan was lower than that in Western countries (36.7 kg/m2 vs 44.0 kg/m2). | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | wiley | en |
dc.rights | This is the peer reviewed version of the following article: Harada, Y., Chihara, Y., Azuma, M., Murase, K., Toyama, Y., Yoshimura, C., Oga, T., Nakamura, H., Mishima, M., Chin, K. and Japan Respiratory Failure Group (2014), Obesity hypoventilation syndrome in Japan and independent determinants of arterial carbon dioxide levels. Respirology, 19: 1233–1240, which has been published in final form at http://dx.doi.org/10.1111/resp.12367. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | diffusion capacity | en |
dc.subject | hypercapnia | en |
dc.subject | hypoventilation | en |
dc.subject | obesity | en |
dc.subject | sleep apnoea | en |
dc.title | Obesity hypoventilation syndrome in Japan and independent determinants of arterial carbon dioxide levels. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Respirology | en |
dc.identifier.volume | 19 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 1233 | - |
dc.identifier.epage | 1240 | - |
dc.relation.doi | 10.1111/resp.12367 | - |
dc.textversion | author | - |
dc.startdate.bitstreamsavailable | 2015-09-10 | - |
dc.identifier.pmid | 25208458 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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