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タイトル: | Obesity hypoventilation syndrome in Japan and independent determinants of arterial carbon dioxide levels. |
著者: | Harada, Yuka Chihara, Yuichi Azuma, Masanori Murase, Kimihiko Toyama, Yoshiro Yoshimura, Chikara Oga, Toru Nakamura, Hiroshi Mishima, Michiaki Chin, Kazuo Japan Respiratory Failure Group |
著者名の別形: | 陳, 和夫 |
キーワード: | diffusion capacity hypercapnia hypoventilation obesity sleep apnoea |
発行日: | 10-Sep-2014 |
出版者: | wiley |
誌名: | Respirology |
巻: | 19 |
号: | 8 |
開始ページ: | 1233 |
終了ページ: | 1240 |
抄録: | [Background and objective]Obesity hypoventilation syndrome (OHS) prevalence was previously estimated at 9% in patients with obstructive sleep apnoea (OSA) in Japan. However, the definition of OSA in that study was based on an apnoea-hypopnoea index (AHI) of ≥ 20/h rather than ≥ 5/h. Therefore, the prevalence of OHS in OSA was not measured in the same way as for Western countries. Our study objectives were to investigate the characteristics of Japanese patients with OHS. [Methods]Nine hundred eighty-one consecutive patients investigated for suspected OSA were enrolled. At least 90% of them were from urban areas, including 162 with obese OSA (body mass index (BMI) ≥ 30 kg/m2 and AHI ≥ 5/h). [Results]The prevalence of OHS (BMI 36.7 ± 4.9 kg/m2) in OSA and that in obese OSA were 2.3% and 12.3%, respectively. Multiple regression analysis revealed that independent of age and BMI, arterial oxygen pressure (contribution rate (R2) = 7.7%), 4% oxygen desaturation index (R2 = 8.9%), carbon monoxide diffusing capacity/alveolar volume (R2 = 8.3%), haemoglobin concentration (R2 = 4.9%) and waist circumference (R2 = 4.9%) were independently associated with arterial carbon dioxide pressure. After 12.3 ± 4.6 months of CPAP treatment, more than 60% of OHS patients no longer had hypercapnia. [Conclusions]The prevalence of OHS in OSA in Japan was 2.3%. The mean BMI of patients with OHS in Japan was lower than that in Western countries (36.7 kg/m2 vs 44.0 kg/m2). |
著作権等: | This is the peer reviewed version of the following article: Harada, Y., Chihara, Y., Azuma, M., Murase, K., Toyama, Y., Yoshimura, C., Oga, T., Nakamura, H., Mishima, M., Chin, K. and Japan Respiratory Failure Group (2014), Obesity hypoventilation syndrome in Japan and independent determinants of arterial carbon dioxide levels. Respirology, 19: 1233–1240, which has been published in final form at http://dx.doi.org/10.1111/resp.12367. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/200266 |
DOI(出版社版): | 10.1111/resp.12367 |
PubMed ID: | 25208458 |
出現コレクション: | 学術雑誌掲載論文等 |
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