Downloads: 336

Files in This Item:
File Description SizeFormat 
j.schres.2015.03.009.pdf313.2 kBAdobe PDFView/Open
Title: Creativity and positive symptoms in schizophrenia revisited: Structural connectivity analysis with diffusion tensor imaging.
Authors: Son, Shuraku
Kubota, Manabu
Miyata, Jun  kyouindb  KAKEN_id
Fukuyama, Hidenao
Aso, Toshihiko  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-4814-089X (unconfirmed)
Urayama, Shin-ichi
Murai, Toshiya
Takahashi, Hidehiko
Author's alias: 孫, 樹洛
高橋, 英彦
Keywords: Automatic spreading activation
Phonological fluency
Delusions
Interhemispheric dysconnectivity
Executive dysfunction
Corpus callosum
Issue Date: May-2015
Publisher: Elsevier B.V.
Journal title: Schizophrenia research
Volume: 164
Issue: 1-3
Start page: 221
End page: 226
Abstract: Both creativity and schizotypy are suggested to be manifestations of the hyperactivation of unusual or remote concepts/words. However, the results of studies on creativity in schizophrenia are diverse, possibly due to the multifaceted aspects of creativity and difficulties of differentiating adaptive creativity from pathological schizotypy/positive symptoms. To date, there have been no detailed studies comprehensively investigating creativity, positive symptoms including delusions, and their neural bases in schizophrenia. In this study, we investigated 43 schizophrenia and 36 healthy participants using diffusion tensor imaging. We used idea, design, and verbal (semantic and phonological) fluency tests as creativity scores and Peters Delusions Inventory as delusion scores. Subsequently, we investigated group differences in every psychological score, correlations between fluency and delusions, and relationships between these scores and white matter integrity using tract-based spatial statistics (TBSS). In schizophrenia, idea and verbal fluency were significantly lower in general, and delusion score was higher than in healthy controls, whereas there were no group differences in design fluency. We also found positive correlation between phonological fluency and delusions in schizophrenia. By correlation analyses using TBSS, we found that the anterior part of corpus callosum was the substantially overlapped area, negatively correlated with both phonological fluency and delusion severity. Our results suggest that the anterior interhemispheric dysconnectivity might be associated with executive dysfunction, and disinhibited automatic spreading activation in the semantic network was manifested as uncontrollable phonological fluency or delusions. This dysconnectivity could be one possible neural basis that differentiates pathological positive symptoms from adaptive creativity.
Rights: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
The full-text file will be made open to the public on 31 May 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/201402
DOI(Published Version): 10.1016/j.schres.2015.03.009
PubMed ID: 25823399
Appears in Collections:Journal Articles

Show full item record

Export to RefWorks


Export Format: 


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.