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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| cbic.201500140.pdf | 1.57 MB | Adobe PDF | 見る/開く |
| タイトル: | A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts. |
| 著者: | Syed, Junetha Chandran, Anandhakumar Pandian, Ganesh N Taniguchi, Junichi Sato, Shinsuke Hashiya, Kaori Kashiwazaki, Gengo Bando, Toshikazu   Sugiyama, Hiroshi  https://orcid.org/0000-0001-8923-5946 (unconfirmed) |
| 著者名の別形: | 杉山, 弘 |
| キーワード: | artificial transcription activators DNA recognition gene expression histone acetylation transcription profiling |
| 発行日: | 28-May-2015 |
| 出版者: | wiley |
| 誌名: | Chembiochem |
| 巻: | 16 |
| 号: | 10 |
| 開始ページ: | 1497 |
| 終了ページ: | 1501 |
| 抄録: | Small molecules capable of modulating epigenetic signatures can activate the transcription of tissue-restricted genes in a totally unrelated cell type and have potential use in epigenetic therapy. To provide an example for an initial approach, we report here on one synthetic small-molecule compound-termed "SAHA-PIP X"-from our library of conjugates. This compound triggered histone acetylation accompanied by the transcription of retinal-tissue-related genes in human dermal fibroblasts (HDFs). |
| 著作権等: | This is the peer reviewed version of the following article: Syed, J., Chandran, A., Pandian, G. N., Taniguchi, J., Sato, S., Hashiya, K., Kashiwazaki, G., Bando, T. and Sugiyama, H. (2015), A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts. ChemBioChem, 16: 1497–1501, which has been published in final form at http://dx.doi.org/10.1002/cbic.201500140. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. The full-text file will be made open to the public on 28 May 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| URI: | http://hdl.handle.net/2433/201619 |
| DOI(出版社版): | 10.1002/cbic.201500140 |
| PubMed ID: | 25900774 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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