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dc.contributor.author | Miyake, Yuka | en |
dc.contributor.author | Kimura, Yu | en |
dc.contributor.author | Orito, Naomi | en |
dc.contributor.author | Imai, Hirohiko | en |
dc.contributor.author | Matsuda, Tetsuya | en |
dc.contributor.author | Toshimitsu, Akio | en |
dc.contributor.author | Kondo, Teruyuki | en |
dc.contributor.alternative | 近藤, 輝幸 | ja |
dc.date.accessioned | 2015-11-26T02:32:33Z | - |
dc.date.available | 2015-11-26T02:32:33Z | - |
dc.date.issued | 2015-07-01 | - |
dc.identifier.issn | 0040-4020 | - |
dc.identifier.uri | http://hdl.handle.net/2433/201952 | - |
dc.description.abstract | Novel chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups were synthesized and shown to have longitudinal relaxivity (r1) values 5 times higher than that of clinically used Gd-DTPA. The affinities of Gd-4a and Gd-4b for bovine serum albumin (BSA), respectively, were estimated by a quartz crystal microbalance (QCM) measurement. The amino groups of the dendrimer were then conjugated with PEG. This conjugation with PEG strongly affected its ability to attenuate signals in T1-weighted MRI. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ltd. | en |
dc.rights | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.rights | The full-text file will be made open to the public on 1 July 2017 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | Chiral dendrimer | en |
dc.subject | MRI contrast agent | en |
dc.subject | Gadolinium | en |
dc.subject | Polyethylene glycol | en |
dc.subject | Molecular imaging | en |
dc.title | Synthesis and functional evaluation of chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups as highly sensitive MRI contrast agents | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00861787 | - |
dc.identifier.jtitle | Tetrahedron | en |
dc.identifier.volume | 71 | - |
dc.identifier.issue | 26-27 | - |
dc.identifier.spage | 4438 | - |
dc.identifier.epage | 4444 | - |
dc.relation.doi | 10.1016/j.tet.2015.04.050 | - |
dc.textversion | author | - |
dc.startdate.bitstreamsavailable | 2017-07-01 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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