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Title: Magnetic resonance imaging of tumor with a self-traceable polymer conjugated with an antibody fragment.
Authors: Yamada, Hisatsugu
Hasegawa, Yoshinori
Suzuki, Yuki
Imai, Hirohiko  kyouindb  KAKEN_id
Matsuda, Tetsuya  kyouindb  KAKEN_id  orcid (unconfirmed)
Kimura, Yu  kyouindb  KAKEN_id  orcid (unconfirmed)
Toshimitsu, Akio
Aoyama, Yasuhiro
Kondo, Teruyuki
Author's alias: 近藤, 輝幸
Keywords: Tumor imaging
Self-traceable polymer
Anti-Her2 antibody
Active targeting
Issue Date: 1-Jul-2015
Publisher: Elsevier Ltd.
Journal title: Bioorganic & medicinal chemistry letters
Volume: 25
Issue: 13
Start page: 2675
End page: 2678
Abstract: A (13)C-enriched phosphorylcholine polymer ((13)C-PMPC) as a self-traceable MR (magnetic resonance) tag was conjugated with a fragment (scFv) of Herceptin, a clinical antibody against antigen Her2. When injected in model mice bearing Her2(+) (gastric) and Her2(-) (pancreatic) tumors, the antibody-tag conjugate (13)C-PMPC-scFv selectively accumulated in the Her2(+) tumor with a rapid build-up/decay (accumulation/clearance) profile and, with the use of the (1)H-(13)C double-resonance (heteronuclear correlation) technique, the Her2(+) gastric tumor was clearly MR imaged.
Rights: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
The full-text file will be made open to the public on 1 July 2017 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.bmcl.2015.04.072
PubMed ID: 25958246
Appears in Collections:Journal Articles

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