|Title:||Magnetic resonance imaging of tumor with a self-traceable polymer conjugated with an antibody fragment.|
Matsuda, Tetsuya https://orcid.org/0000-0002-2339-1521 (unconfirmed)
Kimura, Yu https://orcid.org/0000-0001-5318-9255 (unconfirmed)
|Author's alias:||近藤, 輝幸|
|Journal title:||Bioorganic & medicinal chemistry letters|
|Abstract:||A (13)C-enriched phosphorylcholine polymer ((13)C-PMPC) as a self-traceable MR (magnetic resonance) tag was conjugated with a fragment (scFv) of Herceptin, a clinical antibody against antigen Her2. When injected in model mice bearing Her2(+) (gastric) and Her2(-) (pancreatic) tumors, the antibody-tag conjugate (13)C-PMPC-scFv selectively accumulated in the Her2(+) tumor with a rapid build-up/decay (accumulation/clearance) profile and, with the use of the (1)H-(13)C double-resonance (heteronuclear correlation) technique, the Her2(+) gastric tumor was clearly MR imaged.|
|Rights:||© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/|
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|Appears in Collections:||Journal Articles|
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