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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| j.bmcl.2015.04.072.pdf | 529.77 kB | Adobe PDF | 見る/開く |
| タイトル: | Magnetic resonance imaging of tumor with a self-traceable polymer conjugated with an antibody fragment. |
| 著者: | Yamada, Hisatsugu Hasegawa, Yoshinori Suzuki, Yuki Imai, Hirohiko   Matsuda, Tetsuya  https://orcid.org/0000-0002-2339-1521 (unconfirmed)Kimura, Yu https://orcid.org/0000-0001-5318-9255 (unconfirmed)Toshimitsu, Akio Aoyama, Yasuhiro Kondo, Teruyuki |
| 著者名の別形: | 近藤, 輝幸 |
| キーワード: | Tumor imaging MRI Self-traceable polymer Anti-Her2 antibody Active targeting |
| 発行日: | 1-Jul-2015 |
| 出版者: | Elsevier Ltd. |
| 誌名: | Bioorganic & medicinal chemistry letters |
| 巻: | 25 |
| 号: | 13 |
| 開始ページ: | 2675 |
| 終了ページ: | 2678 |
| 抄録: | A (13)C-enriched phosphorylcholine polymer ((13)C-PMPC) as a self-traceable MR (magnetic resonance) tag was conjugated with a fragment (scFv) of Herceptin, a clinical antibody against antigen Her2. When injected in model mice bearing Her2(+) (gastric) and Her2(-) (pancreatic) tumors, the antibody-tag conjugate (13)C-PMPC-scFv selectively accumulated in the Her2(+) tumor with a rapid build-up/decay (accumulation/clearance) profile and, with the use of the (1)H-(13)C double-resonance (heteronuclear correlation) technique, the Her2(+) gastric tumor was clearly MR imaged. |
| 著作権等: | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ The full-text file will be made open to the public on 1 July 2017 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
| URI: | http://hdl.handle.net/2433/201953 |
| DOI(出版社版): | 10.1016/j.bmcl.2015.04.072 |
| PubMed ID: | 25958246 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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