|Title:||Convenient synthesis of spiroindole derivatives via palladium-catalyzed cyclization of propargyl chlorides|
Inuki, Shinsuke https://orcid.org/0000-0002-7525-1280 (unconfirmed)
Oishi, Shinya https://orcid.org/0000-0002-2833-2539 (unconfirmed)
Ohno, Hiroaki https://orcid.org/0000-0002-3246-4809 (unconfirmed)
|Author's alias:||藤井, 信孝|
Catalytic asymmetric reaction
|Abstract:||Herein, we report the palladium-catalyzed cyclization reactions of indoles bearing a propargyl chloride side chain at their 3-position. In the presence of an external nucleophile, such as a sulfonamide or malonate, indoles bearing a propargyl group at their 3-position gave fused tetracyclic spiroindolines preferentially. However, in the absence of an external nucleophile, the same substrates afforded spiroindoles. Our attempts to develop a catalytic asymmetric spirocyclization onto a propargylpalladium species are also presented in this paper.|
|Description:||Available online 9 May 2015|
|Rights:||© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/|
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|Appears in Collections:||Journal Articles|
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