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Title: Increased number of peripheral CD8(+) T cells but not eosinophils is associated with late-onset skin reactions caused by bendamustine.
Authors: Nishikori, Momoko  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-4171-2162 (unconfirmed)
Kitano, Toshiyuki
Kobayashi, Masayuki
Hishizawa, Masakatsu
Kitawaki, Toshio  kyouindb  KAKEN_id
Kondo, Tadakazu  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-8959-6271 (unconfirmed)
Yamashita, Kouhei
Kawabata, Hiroshi
Kadowaki, Norimitsu
Takei, Yusuke
Haga, Hironori  kyouindb  KAKEN_id
Takaori-Kondo, Akifumi
Author's alias: 錦織, 桃子
Keywords: Bendamustine
Skin reactions
CD8(+) T cells
Cytomegalovirus
Issue Date: Jul-2015
Publisher: Springer Japan
Journal title: International journal of hematology
Volume: 102
Issue: 1
Start page: 53
End page: 58
Abstract: Bendamustine is a chemotherapeutic drug that has recently come to be used frequently in the treatment of indolent B cell lymphomas. Skin toxicity is recognized as one of its characteristic side effects, but detailed information on such reactions has not yet been obtained. To clarify the clinical features of skin toxicity associated with bendamustine, we retrospectively analyzed skin reactions that developed in patients treated with bendamustine and rituximab (BR). Of 34 patients treated with 3-6 cycles of BR, 11 developed late-onset, persistent skin eruptions. These patients demonstrated increases in CD8(+) T cell number and CD8(+):CD4(+) cell ratio at the end of chemotherapy. In contrast, peripheral eosinophil count was not associated with such adverse events, whereas eosinophil infiltration was frequently observed in the skin. Patients with skin reactions tended to have higher seropositivity of hepatitis B core antibody, and multiplex viral screening PCR of the frozen sera demonstrated cytomegalovirus-DNA in some of the eruption-positive patients. It is speculated that inappropriate activation of CD8(+) T cells by latently infected pathogens may be one of the triggers of late-onset skin reactions caused by bendamustine.
Description: First online: 02 April 2015
Rights: The final publication is available at Springer via http://dx.doi.org/10.1007/s12185-015-1791-3.
The full-text file will be made open to the public on 02 April 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/202063
DOI(Published Version): 10.1007/s12185-015-1791-3
PubMed ID: 25833722
Appears in Collections:Journal Articles

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