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dc.contributor.authorIzuhara, Masayasuja
dc.contributor.authorOno, Kohja
dc.contributor.authorShiomi, Hirokija
dc.contributor.authorMorimoto, Takeshija
dc.contributor.authorFurukawa, Yutakaja
dc.contributor.authorNakagawa, Yoshihisaja
dc.contributor.authorShizuta, Satoshija
dc.contributor.authorTada, Tomohisaja
dc.contributor.authorTazaki, Junichija
dc.contributor.authorHorie, Takahiroja
dc.contributor.authorKuwabara, Yasuhideja
dc.contributor.authorBaba, Osamuja
dc.contributor.authorNishino, Tomohiroja
dc.contributor.authorKita, Toruja
dc.contributor.authorKimura, Takeshija
dc.contributor.alternative尾野, 亘ja
dc.description.abstract[Objective]To determine whether low HDL-C is a risk factor for adverse cardiovascular events in patients with known CAD. [Methods]We evaluated 10, 391 patients who underwent PCI from January 2005 to December 2007. In total, 3838 (36.9%) patients had low HDL-C (HDL-C <40 mg/dL in males and <50 mg/dL in females) and 6553 (63.1%) patients had normal HDL-C based on measurements on admission. [Results]The unadjusted 5-year incidence of major adverse cardiac events (MACE: composite of cardiovascular death, myocardial infarction or stroke) was significantly higher in the low HDL-C group than in the normal HDL-C group (17.6% vs. 14.0%, P < 0.0001). However, after adjusting for confounders, low HDL-C was not associated with a higher risk of MACE (adjusted hazard ratio [HR] 1.07, 95% confidence interval (CI) 0.97?1.19; P = 0.19). There was no significant interaction between the effect of low HDL-C on MACE and several subgroup factors including age, sex, clinical presentation of CAD, statins use, serum low-density lipoprotein cholesterol level, and serum triglycerides level. [Conclusion]Low HDL-C, as compared with normal HDL-C, was not associated with higher 5-year risk of MACE in patients who underwent PCI.ja
dc.publisherElsevier Ltd.ja
dc.rightsc 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NCND license (
dc.subjectLipoprotein cholesterolja
dc.subjectMyocardial infarctionja
dc.subjectPercutaneous coronary interventionja
dc.titleHigh-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: a report from the CREDO-Kyoto registry cohort-2.ja
dc.type.niitypeJournal Articleja
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