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j.atherosclerosis.2015.05.010.pdf | 1.23 MB | Adobe PDF | 見る/開く |
タイトル: | High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: a report from the CREDO-Kyoto registry cohort-2. |
著者: | Izuhara, Masayasu Ono, Koh Shiomi, Hiroki Morimoto, Takeshi Furukawa, Yutaka Nakagawa, Yoshihisa Shizuta, Satoshi Tada, Tomohisa Tazaki, Junichi Horie, Takahiro Kuwabara, Yasuhide Baba, Osamu Nishino, Tomohiro Kita, Toru Kimura, Takeshi |
著者名の別形: | 尾野, 亘 |
キーワード: | High-density Lipoprotein cholesterol Myocardial infarction Percutaneous coronary intervention Statin |
発行日: | Oct-2015 |
出版者: | Elsevier Ltd. |
誌名: | Atherosclerosis |
巻: | 242 |
号: | 2 |
開始ページ: | 632 |
終了ページ: | 638 |
抄録: | [Objective]To determine whether low HDL-C is a risk factor for adverse cardiovascular events in patients with known CAD. [Methods]We evaluated 10, 391 patients who underwent PCI from January 2005 to December 2007. In total, 3838 (36.9%) patients had low HDL-C (HDL-C <40 mg/dL in males and <50 mg/dL in females) and 6553 (63.1%) patients had normal HDL-C based on measurements on admission. [Results]The unadjusted 5-year incidence of major adverse cardiac events (MACE: composite of cardiovascular death, myocardial infarction or stroke) was significantly higher in the low HDL-C group than in the normal HDL-C group (17.6% vs. 14.0%, P < 0.0001). However, after adjusting for confounders, low HDL-C was not associated with a higher risk of MACE (adjusted hazard ratio [HR] 1.07, 95% confidence interval (CI) 0.97?1.19; P = 0.19). There was no significant interaction between the effect of low HDL-C on MACE and several subgroup factors including age, sex, clinical presentation of CAD, statins use, serum low-density lipoprotein cholesterol level, and serum triglycerides level. [Conclusion]Low HDL-C, as compared with normal HDL-C, was not associated with higher 5-year risk of MACE in patients who underwent PCI. |
著作権等: | c 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NCND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
URI: | http://hdl.handle.net/2433/202588 |
DOI(出版社版): | 10.1016/j.atherosclerosis.2015.05.010 |
PubMed ID: | 26022139 |
出現コレクション: | 学術雑誌掲載論文等 |
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