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タイトル: Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour.
著者: Doi, Masao  kyouindb  KAKEN_id
Murai, Iori
Kunisue, Sumihiro
Setsu, Genzui
Uchio, Naohiro
Tanaka, Rina
Kobayashi, Sakurako
Shimatani, Hiroyuki
Hayashi, Hida
Chao, Hsu-Wen
Nakagawa, Yuuki
Takahashi, Yukari
Hotta, Yunhong
Yasunaga, Jun-Ichirou
Matsuoka, Masao
Hastings, Michael H
Kiyonari, Hiroshi
Okamura, Hitoshi
著者名の別形: 土居, 雅夫
岡村, 均
キーワード: Biological sciences
Cell biology
Neuroscience
発行日: 17-Feb-2016
出版者: Nature Publishing Group
誌名: Nature communications
巻: 7
論文番号: 10583
抄録: G-protein-coupled receptors (GPCRs) participate in a broad range of physiological functions. A priority for fundamental and clinical research, therefore, is to decipher the function of over 140 remaining orphan GPCRs. The suprachiasmatic nucleus (SCN), the brain's circadian pacemaker, governs daily rhythms in behaviour and physiology. Here we launch the SCN orphan GPCR project to (i) search for murine orphan GPCRs with enriched expression in the SCN, (ii) generate mutant animals deficient in candidate GPCRs, and (iii) analyse the impact on circadian rhythms. We thereby identify Gpr176 as an SCN-enriched orphan GPCR that sets the pace of circadian behaviour. Gpr176 is expressed in a circadian manner by SCN neurons, and molecular characterization reveals that it represses cAMP signalling in an agonist-independent manner. Gpr176 acts independently of, and in parallel to, the Vipr2 GPCR, not through the canonical Gi, but via the unique G-protein subclass Gz.
記述: 体内時計を調節するオーファンGPCRの同定 -生体リズム調整薬の開発に期待-. 京都大学プレスリリース. 2016-02-18.
著作権等: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
URI: http://hdl.handle.net/2433/204599
DOI(出版社版): 10.1038/ncomms10583
PubMed ID: 26882873
関連リンク: http://www.kyoto-u.ac.jp/ja/research/research_results/2015/160217_1.html/
出現コレクション:学術雑誌掲載論文等

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