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Title: Prefrontal spatial working memory network predicts animal's decision making in a free choice saccade task.
Authors: Mochizuki, Kei
Funahashi, Shintaro
Author's alias: 望月, 圭
船橋, 新太郎
Issue Date: 1-Jan-2016
Publisher: 0022-3077
Journal title: American Physiological Society
Volume: 115
Issue: 1
Start page: 127
End page: 142
Abstract: While neurons in the lateral prefrontal cortex (PFC) encode spatial information during the performance of working memory tasks, they are also known to participate in subjective behavior such as spatial attention and action selection. In the present study, we analyzed the activity of primate PFC neurons during the performance of a free choice memory-guided saccade task in which the monkeys needed to choose a saccade direction by themselves. In trials when the receptive field location was subsequently chosen by the animal, PFC neurons with spatially selective visual response started to show greater activation before cue onset. This result suggests that the fluctuation of firing before cue presentation prematurely biased the representation of a certain spatial location and eventually encouraged the subsequent choice of that location. In addition, modulation of the activity by the animal's choice was observed only in neurons with high sustainability of activation and was also dependent on the spatial configuration of the visual cues. These findings were consistent with known characteristics of PFC neurons in information maintenance in spatial working memory function. These results suggest that precue fluctuation of spatial representation was shared and enhanced through the working memory network in the PFC and could finally influence the animal's free choice of saccade direction. The present study revealed that the PFC plays an important role in decision making in a free choice condition and that the dynamics of decision making are constrained by the network architecture embedded in this cortical area.
Description: 自由選択条件で選択を左右する前頭連合野の神経メカニズムを解明. 京都大学プレスリリース. 2015-11-06.
Rights: © 2016 the American Physiological Society
This is the accepted manuscrip of the article is available at
The full-text file will be made open to the public on 1 January 2017 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1152/jn.00255.2015
PubMed ID: 26490287
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