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タイトル: | The Roles of Syncytin-Like Proteins in Ruminant Placentation. |
著者: | Nakaya, Yuki Miyazawa, Takayuki |
著者名の別形: | 仲屋, 友喜 宮沢, 孝幸 |
キーワード: | ruminants endogenous retrovirus envelope glycoprotein fematrin-1 syncytin-rum1 placenta cell-to-cell fusion |
発行日: | 5-Jun-2015 |
出版者: | MDPI |
誌名: | Viruses |
巻: | 7 |
号: | 6 |
開始ページ: | 2928 |
終了ページ: | 2942 |
抄録: | Recent developments in genome sequencing techniques have led to the identification of huge numbers of endogenous retroviruses (ERV) in various mammals. ERVs, which occupy 8%–13% of mammalian genomes, are believed to affect mammalian evolution and biological diversity. Although the functional significance of most ERVs remains to be elucidated, several ERVs are thought to have pivotal roles in host physiology. We and other groups recently identified ERV envelope proteins (e.g., Fematrin-1, Syncytin-Rum1, endogenous Jaagsiekte sheep retrovirus Env) that may determine the morphogenesis of the unique fused trophoblast cells, termed trinucleate cells and syncytial plaques, found in ruminant placentas; however, there are still a number of outstanding issues with regard to the role of ERVs that remain to be resolved. Here, we review what is known about how these ERVs have contributed to the development of ruminant-specific trophoblast cells. |
著作権等: | © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
URI: | http://hdl.handle.net/2433/210838 |
DOI(出版社版): | 10.3390/v7062753 |
PubMed ID: | 26057168 |
出現コレクション: | 学術雑誌掲載論文等 |
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