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Title: The Roles of Syncytin-Like Proteins in Ruminant Placentation.
Authors: Nakaya, Yuki
Miyazawa, Takayuki  kyouindb  KAKEN_id
Author's alias: 仲屋, 友喜
宮沢, 孝幸
Keywords: ruminants
endogenous retrovirus
envelope glycoprotein
fematrin-1
syncytin-rum1
placenta
cell-to-cell fusion
Issue Date: 5-Jun-2015
Publisher: MDPI
Journal title: Viruses
Volume: 7
Issue: 6
Start page: 2928
End page: 2942
Abstract: Recent developments in genome sequencing techniques have led to the identification of huge numbers of endogenous retroviruses (ERV) in various mammals. ERVs, which occupy 8%–13% of mammalian genomes, are believed to affect mammalian evolution and biological diversity. Although the functional significance of most ERVs remains to be elucidated, several ERVs are thought to have pivotal roles in host physiology. We and other groups recently identified ERV envelope proteins (e.g., Fematrin-1, Syncytin-Rum1, endogenous Jaagsiekte sheep retrovirus Env) that may determine the morphogenesis of the unique fused trophoblast cells, termed trinucleate cells and syncytial plaques, found in ruminant placentas; however, there are still a number of outstanding issues with regard to the role of ERVs that remain to be resolved. Here, we review what is known about how these ERVs have contributed to the development of ruminant-specific trophoblast cells.
Rights: © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
URI: http://hdl.handle.net/2433/210838
DOI(Published Version): 10.3390/v7062753
PubMed ID: 26057168
Appears in Collections:Journal Articles

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