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Title: Successful treatment with carboplatin and nanoparticle albumin-bound paclitaxel in a patient with pulmonary spindlecellcarcinoma
Authors: Tsuji, Takahiro
Kim, Young Hak  kyouindb  KAKEN_id
Ozasa, Hiroaki  kyouindb  KAKEN_id
Sakamori, Yuichi
Nagai, Hiroki
Ajimizu, Hitomi
Yagi, Yoshitaka
Furukawa, Atsuyuki
Haga, Hironori  kyouindb  KAKEN_id
Mishima, Michiaki
Author's alias: 金, 永学
小笹, 裕見
阪森, 優一
羽賀, 博典
三嶋, 理晃
Keywords: Pulmonary sarcomatoid carcinoma
Spindle cell carcinoma
Nab-PTX
Issue Date: 1-May-2015
Publisher: Elsevier Ltd.
Journal title: Respiratory Medicine Case Reports
Volume: 15
Start page: 48
End page: 50
Abstract: Introduction: Pulmonary spindle cell carcinoma (SpCC) is a rare subtype of non-small-cell lung cancer (NSCLC) and, in general, is chemoresistance. Case: A sixty-five year-old male patient with metastatic pulmonary SpCC was initially treated with cisplatin and docetaxel, but his disease progressed. Then, he received a combination chemotherapy with carboplatin and nab-PTX followed by maintenanced chemotherapy with nab-PTX. Fluorodeoxyglucose (FDG) positron-emission CT revealed a substantial decrease of FDG accumulation in the primary tumor, and the response continued for more than 7 months. Discussion: Preclinical models suggested that nab-PTX may reach the tumor microenvironment more efficiently than solvent-based paclitaxel (sb-PTX) and be preferentially taken up by cancer cells. Considering that there is no effective treatment for patients with pulmonary SpCC, nab-PTX may merit further investigation in patients with pulmonary SpCC.
Rights: © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).
URI: http://hdl.handle.net/2433/215118
DOI(Published Version): 10.1016/j.rmcr.2015.05.003
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