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cas.12816.pdf | 1.57 MB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | Enomoto, Masato | en |
dc.contributor.author | Vaughen, John | en |
dc.contributor.author | Igaki, Tatsushi | en |
dc.contributor.alternative | 井垣, 達吏 | ja |
dc.date.accessioned | 2016-06-23T01:52:37Z | - |
dc.date.available | 2016-06-23T01:52:37Z | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 1349-7006 | - |
dc.identifier.uri | http://hdl.handle.net/2433/215151 | - |
dc.description.abstract | Tumor progression is classically viewed as the Darwinian evolution of subclones that sequentially acquire genetic mutations and autonomously overproliferate. However, growing evidence suggests that tumor microenvironment and subclone heterogeneity contribute to non-autonomous tumor progression. Recent Drosophila studies revealed a common mechanism by which clones of genetically altered cells trigger non-autonomous overgrowth. Such "oncogenic niche cells" (ONCs) do not overgrow but instead stimulate neighbor overgrowth and metastasis. Establishment of ONCs depends on competition and cooperation between heterogeneous cell populations. This review characterizes diverse ONCs identified in Drosophila and describes the genetic basis of non-autonomous tumor progression. Similar mechanisms may contribute to mammalian cancer progression and recurrence. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Blackwell Publishing Ltd | en |
dc.rights | © 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association. | en |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en |
dc.subject | Cell competition | en |
dc.subject | Cell death | en |
dc.subject | Cellular cooperation | en |
dc.subject | Cellular senescence | en |
dc.subject | Tumor progression | en |
dc.title | Non-autonomous overgrowth by oncogenic niche cells: Cellular cooperation and competition in tumorigenesis | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Cancer Science | en |
dc.identifier.volume | 106 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 1651 | - |
dc.identifier.epage | 1658 | - |
dc.relation.doi | 10.1111/cas.12816 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 26362609 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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