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Title: Cleaved form of osteopontin in urine as a clinical marker of lupus nephritis
Authors: Kitagori, Koji
Yoshifuji, Hajime  kyouindb  KAKEN_id  orcid (unconfirmed)
Oku, Takuma
Sasaki, Chiyomi
Miyata, Hitomi
Mori, Keita P.
Nakajima, Toshiki
Ohmura, Koichiro  kyouindb  KAKEN_id
Kawabata, Daisuke
Yukawa, Naoichiro
Imura, Yoshitaka
Murakami, Kosaku  kyouindb  KAKEN_id  orcid (unconfirmed)
Nakashima, Ran
Usui, Takashi
Fujii, Takao
Sakai, Kaoru
Yanagita, Motoko  kyouindb  KAKEN_id
Hirayama, Yoshitaka
Mimori, Tsuneyo
Author's alias: 吉藤, 元
宮田, 仁美
大村, 浩一郎
湯川, 尚一郎
井村, 嘉孝
藤井, 隆夫
柳田, 素子
三森, 経世
Issue Date: 19-Dec-2016
Publisher: Public Library of Science
Journal title: PLOS ONE
Volume: 11
Issue: 12
Thesis number: e0167141
Abstract: We assessed the utility of two forms of osteopontin (OPN), OPN full and its cleaved form (OPN N-half), in plasma and urine as markers of disease activity in lupus nephritis (LN). Samples were collected from patients with systemic lupus erythematosus (SLE) (LN: N = 29, non- LN: N = 27), IgA nephropathy (IgAN) (N = 14), minimal change nephrotic syndrome (MCNS) (N = 5), diabetic nephropathy (DN) (N = 14) and healthy volunteers (HC) (N = 17). While there was no significant difference in urine OPN full concentration between groups, urine OPN N-half concentration was significantly higher in patients with LN than HC (p < 0.05). Moreover, urine OPN N-half was higher in LN patients with overt proteinuria (urine protein/ creatinine ratio: P/C > 0.5) than LN patients with minimal proteinuria (P/C < 0.5, p < 0.0001), and also higher than in DN patients with overt proteinuria (P/C > 0.5, p < 0.01). Urine thrombin activity correlated with urine OPN N-half concentration (p < 0.0001), but not with urine OPN full concentration. These results suggest that urine OPN N-half concentration reflects renal inflammation. Thus, urine OPN N-half may be a novel disease activity marker for LN.
Rights: © 2016 Kitagori et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI(Published Version): 10.1371/journal.pone.0167141
PubMed ID: 27992535
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