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Title: Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide
Authors: Dogishi, Koji
Kodera, Mizuki
Oyama, Shohei
Shirakawa, Hisashi  kyouindb  KAKEN_id
Nakagawa, Takayuki  kyouindb  KAKEN_id
Kaneko, Shuji  kyouindb  KAKEN_id
Author's alias: 白川, 久志
中川, 貴之
金子, 周司
Keywords: Chronic cystitis
Hydrogen peroxide
Painful bladder syndrome
Issue Date: 1-Dec-2015
Publisher: Japanese Pharmacological Society
Journal title: Journal of Pharmacological Sciences
Volume: 129
Start page: 244
End page: 246
Abstract: We previously established a long-lasting cystitis model by an intravesical injection of hydrogen peroxide (H2O2) into mice. In this study, we assessed the pain-related behaviors in the cystitis model. An intravesical injection of 1.5% H2O2 transiently decreased spontaneous locomotor activity at 3 h after injection, indicative of acute spontaneous pain. In contrast, licking response to a bladder distention was slowly observed as licks to the lower abdomen at 7 and 14 days after injection, which was attenuated by amitriptyline and morphine, but not by oxybutynin. These results suggest that H2O2-induced chronic cystitis model shows delayed and long-lasting painful pathological condition.
Rights: © 2015 Japanese Pharmacological Society. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
URI: http://hdl.handle.net/2433/218469
DOI(Published Version): 10.1016/j.jphs.2015.11.003
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