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|---|---|---|---|---|
| j.jphs.2015.11.003.pdf | 554.34 kB | Adobe PDF | 見る/開く |
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| DCフィールド | 値 | 言語 |
|---|---|---|
| dc.contributor.author | Dogishi, Koji | en |
| dc.contributor.author | Kodera, Mizuki | en |
| dc.contributor.author | Oyama, Shohei | en |
| dc.contributor.author | Shirakawa, Hisashi | en |
| dc.contributor.author | Nakagawa, Takayuki | en |
| dc.contributor.author | Kaneko, Shuji | en |
| dc.contributor.alternative | 白川, 久志 | ja |
| dc.contributor.alternative | 中川, 貴之 | ja |
| dc.contributor.alternative | 金子, 周司 | ja |
| dc.date.accessioned | 2017-02-28T03:52:11Z | - |
| dc.date.available | 2017-02-28T03:52:11Z | - |
| dc.date.issued | 2015-12-01 | - |
| dc.identifier.issn | 1347-8648 | - |
| dc.identifier.uri | http://hdl.handle.net/2433/218469 | - |
| dc.description.abstract | We previously established a long-lasting cystitis model by an intravesical injection of hydrogen peroxide (H2O2) into mice. In this study, we assessed the pain-related behaviors in the cystitis model. An intravesical injection of 1.5% H2O2 transiently decreased spontaneous locomotor activity at 3 h after injection, indicative of acute spontaneous pain. In contrast, licking response to a bladder distention was slowly observed as licks to the lower abdomen at 7 and 14 days after injection, which was attenuated by amitriptyline and morphine, but not by oxybutynin. These results suggest that H2O2-induced chronic cystitis model shows delayed and long-lasting painful pathological condition. | en |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | eng | - |
| dc.publisher | Elsevier BV | en |
| dc.rights | © 2015 Japanese Pharmacological Society. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en |
| dc.subject | Chronic cystitis | en |
| dc.subject | Hydrogen peroxide | en |
| dc.subject | Painful bladder syndrome | en |
| dc.title | Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide | en |
| dc.type | journal article | - |
| dc.type.niitype | Journal Article | - |
| dc.identifier.ncid | AA11806667 | - |
| dc.identifier.jtitle | Journal of Pharmacological Sciences | en |
| dc.identifier.volume | 129 | - |
| dc.identifier.spage | 244 | - |
| dc.identifier.epage | 246 | - |
| dc.relation.doi | 10.1016/j.jphs.2015.11.003 | - |
| dc.textversion | publisher | - |
| dc.address | Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University | en |
| dc.address | Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital | en |
| dc.identifier.pmid | 26685753 | - |
| dcterms.accessRights | open access | - |
| dc.identifier.pissn | 1347-8613 | - |
| dc.identifier.eissn | 1347-8648 | - |
| 出現コレクション: | 学術雑誌掲載論文等 | |
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