ダウンロード数: 205
このアイテムのファイル:
| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| j.jphs.2015.11.003.pdf | 554.34 kB | Adobe PDF | 見る/開く |
| タイトル: | Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide |
| 著者: | Dogishi, Koji Kodera, Mizuki Oyama, Shohei Shirakawa, Hisashi    https://orcid.org/0000-0002-4129-0978 (unconfirmed)Nakagawa, Takayuki https://orcid.org/0000-0003-1890-0843 (unconfirmed)Kaneko, Shuji https://orcid.org/0000-0001-5152-5809 (unconfirmed) |
| 著者名の別形: | 白川, 久志 中川, 貴之 金子, 周司 |
| キーワード: | Chronic cystitis Hydrogen peroxide Painful bladder syndrome |
| 発行日: | 1-Dec-2015 |
| 出版者: | Elsevier BV |
| 誌名: | Journal of Pharmacological Sciences |
| 巻: | 129 |
| 開始ページ: | 244 |
| 終了ページ: | 246 |
| 抄録: | We previously established a long-lasting cystitis model by an intravesical injection of hydrogen peroxide (H2O2) into mice. In this study, we assessed the pain-related behaviors in the cystitis model. An intravesical injection of 1.5% H2O2 transiently decreased spontaneous locomotor activity at 3 h after injection, indicative of acute spontaneous pain. In contrast, licking response to a bladder distention was slowly observed as licks to the lower abdomen at 7 and 14 days after injection, which was attenuated by amitriptyline and morphine, but not by oxybutynin. These results suggest that H2O2-induced chronic cystitis model shows delayed and long-lasting painful pathological condition. |
| 著作権等: | © 2015 Japanese Pharmacological Society. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| URI: | http://hdl.handle.net/2433/218469 |
| DOI(出版社版): | 10.1016/j.jphs.2015.11.003 |
| PubMed ID: | 26685753 |
| 出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。