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Title: Paraneoplastic limbic encephalitis in a human epidermal growth factor receptor-2-positive gastric cancer patient treated with trastuzumab-combined chemotherapy: A case report and literature review
Authors: Uneno, Yu
Yokoyama, Akira  kyouindb  KAKEN_id
Nishikawa, Yoshitaka  kyouindb  KAKEN_id  orcid (unconfirmed)
Funakoshi, Taro
Ozaki, Yoshinao
Aoyama, Ikuo
Baba, Kiichiro
Yamaguchi, Daisuke
Morita, Shuko
Mori, Yukiko  kyouindb  KAKEN_id
Kanai, Masashi  kyouindb  KAKEN_id
Kinoshita, Hisanori
Inoue, Takeshi
Sawamoto, Nobukatsu  kyouindb  KAKEN_id
Matsumoto, Riki  kyouindb  KAKEN_id  orcid (unconfirmed)
Matsumoto, Shigemi  kyouindb  KAKEN_id
Muto, Manabu  kyouindb  KAKEN_id
Author's alias: 青山, 育雄
金井, 雅史
澤本, 伸克
松本, 繁巳
武藤, 学
Keywords: gastric cancer
paraneoplastic limbic encephalitis
anti-Hu antibody
Issue Date: 2016
Publisher: Japanese Society of Internal Medicine
Journal title: Internal Medicine
Volume: 55
Issue: 18
Start page: 2605
End page: 2609
Abstract: Paraneoplastic neurological syndromes (PNSs) are rare nervous system dysfunctions in cancer patients, which are primarily observed with small-cell lung cancer, gynecological cancer, and thymoma. We herein present an uncommon case of PNS in an anti-Hu antibody-positive patient with human epidermal growth factor receptor (HER)-2-positive gastric cancer (GC), who developed limbic encephalitis and a worsening cognitive function. Trastuzumab-combined chemotherapy was initiated and appeared to be partially effective for controlling the neurological symptoms and tumor volume. Chemotherapy failure eventually led to uncontrollable neurological symptoms. This is the first case demonstrating that trastuzumab-combined chemotherapy may be effective for controlling neurological symptoms of PNS in HER2-positive GC patients.
Rights: © 2016 The Japanese Society of Internal Medicine.
The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (
DOI(Published Version): 10.2169/internalmedicine.55.6917
Appears in Collections:Journal Articles

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