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タイトル: Clinical relevance of reduced decorrelation signals in the diabetic inner choroid on optical coherence tomography angiography
著者: Dodo, Yoko
Suzuma, Kiyoshi
Ishihara, Kenji
Yoshitake, Shin
Fujimoto, Masahiro
Yoshitake, Tatsuya
Miwa, Yuko
Murakami, Tomoaki
著者名の別形: 百々, 蓉子
鈴間, 潔
石原, 健司
吉武, 信
藤本, 雅大
吉武, 達哉
三輪, 裕子
村上, 智昭
キーワード: Medical imaging
Retinal diseases
発行日: 12-Jul-2017
出版者: Springer Nature
誌名: Scientific Reports
巻: 7
論文番号: 5227
抄録: Diabetes induces lesions of the retinal and choroidal capillaries, which promote the pathogenesis of diabetic retinopathy (DR). The decorrelation signals in optical coherence tomography angiography (OCTA) represent the blood flow and vascular structure, and three-dimensional OCTA images enable individual capillary layers to be evaluated separately. The current study documented that en-face OCTA images revealed spots of flow void in the choriocapillaris layer in eyes with DR. Quantitative investigation demonstrated that non-flow areas within the central subfield (CSF) increased in eyes with more severe DR grades. The non-flow areas in the choriocapillaris layer were also associated with poorer visual acuity (VA) in all 108 eyes. A modest correlation was noted between the areas of flow void and poorer VA in 69 eyes without DME, whereas the non-flow areas were not related to VA or to CSF thickness measured by OCT in 39 eyes with DME. In 12 eyes with ischemic maculopathy, the choriocapillaris layer beneath the disrupted ellipsoid zone of the photoreceptor (EZ) had greater areas of flow void than did the area beneath an intact EZ. These data suggested that disrupted choroidal circulation has clinical relevance and contributes to the pathogenesis of DR.
著作権等: © The Author(s) 2017.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
URI: http://hdl.handle.net/2433/228161
DOI(出版社版): 10.1038/s41598-017-05663-9
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