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タイトル: | Wide-range screening of anti-inflammatory compounds in tomato using LC-MS and elucidating the mechanism of their functions. |
著者: | S, Mohri H, Takahashi M, Sakai S, Takahashi N, Waki K, Aizawa H, Suganuma T, Ara Y, Matsumura D, Shibata T, Goto T, Kawada |
著者名の別形: | 毛利, 晋輔 高橋, 春弥 高橋, 慎吾 脇, 尚子 荒, 武 松村, 康生 柴田, 大輔 後藤, 剛 河田, 照雄 |
発行日: | 12-Jan-2018 |
出版者: | Public Library of Science (PLoS) |
誌名: | PloS one |
巻: | 13 |
号: | 1 |
論文番号: | e0191203 |
抄録: | Obesity-induced chronic inflammation is a key factor in type 2 diabetes. A vicious cycle involving pro-inflammatory mediators between adipocytes and macrophages is a common cause of chronic inflammation in the adipose tissue. Tomato is one of the most popular vegetables and is associated with a reduced risk of diabetes. However, the molecular mechanism underlying the effect of tomato on diabetes is unclear. In this study, we focused on anti-inflammatory compounds in tomato. We found that the extract of tomato reduced plasma glucose and inflammatory markers in mice. We screened anti-inflammatory fractions in tomato using lipopolysaccharide-stimulated RAW264.7 macrophages, and active compounds were estimated by liquid chromatography-mass spectrometry over a wide range. Surprisingly, a large number of compounds including oxylipin and coumarin derivatives were estimated as anti-inflammatory compounds. Especially, 9-oxo-octadecadienoic acid and daphnetin suppressed pro-inflammatory cytokines in RAW264.7 macrophages inhibiting mitogen-activated protein kinase phosphorylation and inhibitor of kappa B α protein degradation. These findings suggest that tomato containing diverse anti-inflammatory compounds ameliorates chronic inflammation in obese adipose tissue. |
著作権等: | © 2018 Mohri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | http://hdl.handle.net/2433/230702 |
DOI(出版社版): | 10.1371/journal.pone.0191203 |
PubMed ID: | 29329333 |
出現コレクション: | 学術雑誌掲載論文等 |
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