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ファイル | 記述 | サイズ | フォーマット | |
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j.alit.2017.10.002.pdf | 2.58 MB | Adobe PDF | 見る/開く |
タイトル: | Barrier dysfunction in the skin allergy |
著者: | Egawa, Gyohei Kabashima, Kenji https://orcid.org/0000-0002-0773-0554 (unconfirmed) |
著者名の別形: | 江川, 形平 椛島, 健治 |
キーワード: | Atopic dermatitis Barrier function Cornified envelope Stratum corneum Tight junction |
発行日: | Jan-2018 |
出版者: | Elsevier BV |
誌名: | Allergology International |
巻: | 67 |
号: | 1 |
開始ページ: | 3 |
終了ページ: | 11 |
抄録: | The skin is continuously exposed to external pathogens, and its barrier function is critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one of the most predisposing factors for the development of skin allergic diseases such as atopic dermatitis. In this article, we summarize how the physical barrier of the skin is organized and review its link to the pathomechanism of skin allergic diseases. We describe the formation of the SC barrier in terms of the following five categories: 1) filaggrin metabolism; 2) cornified envelope; 3) intercellular lipids; 4) corneodesmosome; and 5) corneocyte desquamation. New approaches to restoring the skin barrier function are also discussed. |
著作権等: | © 2017, Japanese Society of Allergology. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
URI: | http://hdl.handle.net/2433/230801 |
DOI(出版社版): | 10.1016/j.alit.2017.10.002 |
PubMed ID: | 29153780 |
出現コレクション: | 学術雑誌掲載論文等 |
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