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Title: Barrier dysfunction in the skin allergy
Authors: Egawa, Gyohei  kyouindb  KAKEN_id
Kabashima, Kenji
Author's alias: 江川, 形平
椛島, 健治
Keywords: Atopic dermatitis
Barrier function
Cornified envelope
Stratum corneum
Tight junction
Issue Date: Jan-2018
Publisher: Elsevier BV
Journal title: Allergology International
Volume: 67
Issue: 1
Start page: 3
End page: 11
Abstract: The skin is continuously exposed to external pathogens, and its barrier function is critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one of the most predisposing factors for the development of skin allergic diseases such as atopic dermatitis. In this article, we summarize how the physical barrier of the skin is organized and review its link to the pathomechanism of skin allergic diseases. We describe the formation of the SC barrier in terms of the following five categories: 1) filaggrin metabolism; 2) cornified envelope; 3) intercellular lipids; 4) corneodesmosome; and 5) corneocyte desquamation. New approaches to restoring the skin barrier function are also discussed.
Rights: © 2017, Japanese Society of Allergology. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (
DOI(Published Version): 10.1016/j.alit.2017.10.002
PubMed ID: 29153780
Appears in Collections:Journal Articles

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