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dc.contributor.authorZou, Tingtingen
dc.contributor.authorKizaki, Seiichiroen
dc.contributor.authorPandian, Ganesh N.en
dc.contributor.authorSugiyama, Hiroshien
dc.contributor.alternative杉山, 弘ja
dc.date.accessioned2018-04-26T08:05:45Z-
dc.date.available2018-04-26T08:05:45Z-
dc.date.issued2016-06-20-
dc.identifier.issn0947-6539-
dc.identifier.urihttp://hdl.handle.net/2433/230882-
dc.description.abstractTo evaluate the reactivity of antitumor agents in a nucleosome architecture, we conducted in vitro studies to assess the alkylation level of duocarmycin B2 on nucleosomes with core and linker DNA using sequencing gel electrophoresis. Our results suggested that the alkylating efficiencies of duocarmycin B2 were significantly decreased in core DNA and increased at the histone-free linker DNA sites when compared with naked DNA conditions. Our finding that nucleosome assembly alters the accessibility of duocarmycin B2 to duplex DNA could advance its design as an antitumor agent.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherWiley-VCH Verlagen
dc.rightsThis is the accepted version of the following article: [Tingting Zou, Seiichiro Kizaki, Ganesh N. Pandian, Hiroshi Sugiyama. Nucleosome Assembly Alters the Accessibility of the Antitumor Agent Duocarmycin B2 to Duplex DNA. ChemBioChem (2016), 22, 26, 8756-8758], which has been published in final form at https://doi.org/10.1002/chem.201600950. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en
dc.rightsThe full-text file will be made open to the public on 15 June 2017 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.en
dc.rightsThis is not the published version. Please cite only the published version.en
dc.rightsこの論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。ja
dc.subjectaccessibilityen
dc.subjectalkylationen
dc.subjectantitumor agentsen
dc.subjectduocarmycin B2en
dc.subjectnucleosomeen
dc.titleNucleosome Assembly Alters the Accessibility of the Antitumor Agent Duocarmycin B2 to Duplex DNAen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleChemistry - A European Journalen
dc.identifier.volume22-
dc.identifier.issue26-
dc.identifier.spage8756-
dc.identifier.epage8758-
dc.relation.doi10.1002/chem.201600950-
dc.textversionauthor-
dc.addressDepartment of Science, Graduate School of Science, Kyoto Universityen
dc.addressDepartment of Science, Graduate School of Science, Kyoto Universityen
dc.addressInstitute for Integrated Cell-Material Sciences (iCeMS), Kyoto Universityen
dc.addressDepartment of Science, Graduate School of Science, Kyoto University・Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto Universityen
dc.identifier.pmid27123891-
dcterms.accessRightsopen access-
datacite.date.available2017-06-15-
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