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dc.contributor.authorKikukawa, Hiroshi
dc.contributor.authorSakuradani, Eiji
dc.contributor.authorAndo, Akinori
dc.contributor.authorShimizu, Sakayu
dc.contributor.authorOgawa, Jun
dc.contributor.alternative菊川, 寛史
dc.contributor.alternative櫻谷, 英治
dc.contributor.alternative安藤, 晃規
dc.contributor.alternative清水, 昌
dc.contributor.alternative小川, 順
dc.date.accessioned2018-05-21T00:54:44Z-
dc.date.available2018-05-21T00:54:44Z-
dc.date.issued2018-05
dc.identifier.issn2090-1232
dc.identifier.urihttp://hdl.handle.net/2433/231175-
dc.description.abstractThe filamentous fungus Mortierella alpina 1S-4 is capable of accumulating a large amount of triacylglycerol containing C20 polyunsaturated fatty acids (PUFAs). Indeed, triacylglycerol production by M. alpina 1S-4 can reach 20 g/L of culture broth, and the critical cellular signaling and structural PUFA arachidonic acid (ARA) comprises 30%–70% of the total fatty acid. The demonstrated health benefits of functional PUFAs have in turn encouraged the search for rich sources of these compounds, including fungal strains showing enhanced production of specific PUFAs. Screening for mutants and targeted gene manipulation of M. alpina 1S-4 have elucidated the functions of various enzymes involved in PUFA biosynthesis and established lines with improved PUFA productivity. In some cases, these strains have been used for indistrial-scale production of PUFAs, including ARA. In this review, we described practical ARA production through mutant breeding, functional analyses of genes encoding enzymes involved in PUFA biosynthesis, and recent advances in the production of specific PUFAs through molecular breeding of M. alpina 1S-4.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier BV
dc.rights© 2018 Production and hosting by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.subjectArachidonic acid
dc.subjectMortierella alpina
dc.subjectMolecular breeding
dc.subjectFatty acid desaturase
dc.titleArachidonic acid production by the oleaginous fungus Mortierella alpina 1S-4: A review
dc.type.niitypeJournal Article
dc.identifier.jtitleJournal of Advanced Research
dc.identifier.volume11
dc.identifier.spage15
dc.identifier.epage22
dc.relation.doi10.1016/j.jare.2018.02.003
dc.textversionpublisher
dc.addressDivision of Applied Life Sciences, Graduate School of Agriculture, Kyoto University・Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University
dc.addressDivision of Applied Life Sciences, Graduate School of Agriculture, Kyoto University・Institute of Technology and Science, The University of Tokushima
dc.addressDivision of Applied Life Sciences, Graduate School of Agriculture, Kyoto University
dc.addressDivision of Applied Life Sciences, Graduate School of Agriculture, Kyoto University・Department of Bioscience and Biotechnology, Faculty of Bioenvironmental Science, Kyoto Gakuen University
dc.addressDivision of Applied Life Sciences, Graduate School of Agriculture, Kyoto University
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