ダウンロード数: 154
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
j.jtbi.2018.02.013.pdf | 2.42 MB | Adobe PDF | 見る/開く |
完全メタデータレコード
DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Ishimoto, Kenta | en |
dc.contributor.author | Gadêlha, Hermes | en |
dc.contributor.author | Gaffney, Eamonn A. | en |
dc.contributor.author | Smith, David J. | en |
dc.contributor.author | Kirkman-Brown, Jackson | en |
dc.contributor.alternative | 石本, 健太 | ja |
dc.date.accessioned | 2018-07-31T00:16:12Z | - |
dc.date.available | 2018-07-31T00:16:12Z | - |
dc.date.issued | 2018-06-07 | - |
dc.identifier.issn | 0022-5193 | - |
dc.identifier.uri | http://hdl.handle.net/2433/233002 | - |
dc.description.abstract | Remarkably, mammalian sperm maintain a substantive proportion of their progressive swimming speed within highly viscous fluids, including those of the female reproductive tract. Here, we analyse the digital microscopy of a human sperm swimming in a highly viscous, weakly elastic mucus analogue. We exploit principal component analysis to simplify its flagellar beat pattern, from which boundary element calculations are used to determine the time-dependent flow field around the sperm cell. The sperm flow field is further approximated in terms of regularised point forces, and estimates of the mechanical power consumption are determined, for comparison with analogous low viscosity media studies. This highlights extensive differences in the structure of the flows surrounding human sperm in different media, indicating how the cell-cell and cell-boundary hydrodynamic interactions significantly differ with the physical microenvironment. The regularised point force decomposition also provides cell-level information that may ultimately be incorporated into sperm population models. We further observe indications that the core feature in explaining the effectiveness of sperm swimming in high viscosity media is the loss of cell yawing, which is related with a greater density of regularised point force singularities along the axis of symmetry of the flagellar beat to represent the flow field. In turn this implicates a reduction of the wavelength of the distal beat pattern — and hence dynamical wavelength selection of the flagellar beat — as the dominant feature governing the effectiveness of sperm swimming in highly viscous media. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0/) | en |
dc.subject | Sperm motility | en |
dc.subject | Principal component analysis | en |
dc.subject | Low-Reynolds-number flow | en |
dc.subject | Boundary element method | en |
dc.title | Human sperm swimming in a high viscosity mucus analogue | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Journal of Theoretical Biology | - |
dc.identifier.volume | 446 | - |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 10 | - |
dc.relation.doi | 10.1016/j.jtbi.2018.02.013 | - |
dc.textversion | publisher | - |
dc.address | Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford・The Hakubi Center for Advanced Research, Kyoto University・Research Institute for Mathematical Sciences, Kyoto University | en |
dc.address | Department of Mathematics, University of York・Centre for Human Reproductive Science, Birmingham Women’s and Children’s NHS Foundation Trust | en |
dc.address | Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford | en |
dc.address | School of Mathematics, University of Birmingham・Institute for Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham・Centre for Human Reproductive Science, Birmingham Women’s and Children’s NHS Foundation Trust | en |
dc.address | Institute for Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham・Centre for Human Reproductive Science, Birmingham Women’s and Children’s NHS Foundation Trust | en |
dc.identifier.pmid | 29462624 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
![](/dspace/image/articlelinker.gif)
このリポジトリに保管されているアイテムはすべて著作権により保護されています。