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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| s41598-018-21582-9.pdf | 1.31 MB | Adobe PDF | 見る/開く |
| タイトル: | Evaluation of Macaca radiata as a non-human primate model of Dengue virus infection |
| 著者: | Kato, Fumihiro Ishida, Yuki Kawakami, Akihiko Takasaki, Tomohiko Saijo, Masayuki Miura, Tomoyuki    https://orcid.org/0000-0002-1956-2180 (unconfirmed)Hishiki, Takayuki |
| 著者名の別形: | 加藤, 文博 三浦, 智行 日紫喜, 隆行 |
| 発行日: | 21-Feb-2018 |
| 出版者: | Springer Nature |
| 誌名: | Scientific Reports |
| 巻: | 8 |
| 論文番号: | 3421 |
| 抄録: | Dengue virus (DENV) causes a wide range of illnesses in humans, including dengue fever and dengue haemorrhagic fever. Current animal models of DENV infection are limited for understanding infectious diseases in humans. Bonnet monkeys (Macaca radiata), a type of Old World monkey, have been used to study experimental and natural infections by flaviviruses, but Old World monkeys have not yet been used as DENV infection models. In this study, the replication levels of several DENV strains were evaluated using peripheral blood mononuclear cells. Our findings indicated that DENV-4 09-48 strain, isolated from a traveller returning from India in 2009, was a highly replicative virus. Three bonnet monkeys were infected with 09-48 strain and antibody responses were assessed. DENV nonstructural protein 1 antigen was detected and high viraemia was observed. These results indicated that bonnet monkeys and 09-48 strain could be used as a reliable primate model for the study of DENV. |
| 著作権等: | © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| URI: | http://hdl.handle.net/2433/234604 |
| DOI(出版社版): | 10.1038/s41598-018-21582-9 |
| PubMed ID: | 29467430 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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