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Title: Alteration of Venous Drainage Route in Idiopathic Normal Pressure Hydrocephalus and Normal Aging
Authors: Satow, Takeshi
Aso, Toshihiko  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-4814-089X (unconfirmed)
Nishida, Sei
Komuro, Taro
Ueno, Tsukasa  kyouindb  KAKEN_id
Oishi, Naoya  kyouindb  KAKEN_id
Nakagami, Yukako  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-7495-8957 (unconfirmed)
Odagiri, Masashi
Kikuchi, Takayuki
Yoshida, Kazumichi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-8898-079X (unconfirmed)
Ueda, Keita  kyouindb  KAKEN_id
Kunieda, Takeharu
Murai, Toshiya
Miyamoto, Susumu
Fukuyama, Hidenao
Author's alias: 麻生, 俊彦
西田, 誠
植野, 司
大石, 直也
中神, 由香子
菊池, 隆幸
吉田, 和道
上田, 敬太
國枝, 武治
村井, 俊哉
宮本, 享
福山, 秀直
Keywords: normal pressure hydrocephalus
cerebral venous drainage
normal aging
BOLD signal
low-frequency oscillation in systemic circulation
cerebral blood flow
Issue Date: 23-Nov-2017
Publisher: Frontiers Media SA
Journal title: Frontiers in Aging Neuroscience
Volume: 9
Thesis number: 387
Abstract: Idiopathic normal pressure hydrocephalus (iNPH) is a highly prevalent condition in the elderly population; however, the underlying pathophysiology in relation to the aging process remains unclear. To investigate the effect of removal of cerebrospinal fluid by lumbar “tap test” on the cerebral circulation in patients with iNPH, 14 patients with “probable” iNPH were studied using a novel blood tracking technique based on blood oxygenation level-dependent (BOLD) magnetic resonance signal intensity. By tracking the propagation of the low-frequency component of the BOLD signal, extended venous drainage times were observed in the periventricular region of the patients, which was reversed by tap test. Interestingly, the venous drainage time in the periventricular region exhibited an age-related prolongation in the healthy control group. Additional regression analyses involving 81 control subjects revealed a dissociation of deep and superficial venous systems with increasing age, presumably reflecting focal inefficiency in the deep system. Our results not only provide insights into the etiology of iNPH, but also point to a potential non-invasive biomarker for screening iNPH.
Rights: © 2017 Satow, Aso, Nishida, Komuro, Ueno, Oishi, Nakagami, Odagiri, Kikuchi, Yoshida, Ueda, Kunieda, Murai, Miyamoto and Fukuyama. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
URI: http://hdl.handle.net/2433/234847
DOI(Published Version): 10.3389/fnagi.2017.00387
PubMed ID: 29218007
Appears in Collections:Journal Articles

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