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タイトル: | Palladium-catalyzed double C - H functionalization of arenes at the positions ortho and meta to their directing group: Concise synthesis of benzocyclobutenes |
著者: | Nanjo, Takeshi https://orcid.org/0000-0002-5679-6701 (unconfirmed) Tsukano, Chihiro https://orcid.org/0000-0002-9361-0857 (unconfirmed) Takemoto, Yoshiji https://orcid.org/0000-0003-1375-3821 (unconfirmed) |
著者名の別形: | 南條, 毅 塚野, 千尋 竹本, 佳司 |
キーワード: | C–H functionalization benzocyclobutene palladium directing group double functionalization |
発行日: | 1-Sep-2016 |
出版者: | Pharmaceutical Society of Japan |
誌名: | Chemical and Pharmaceutical Bulletin |
巻: | 64 |
号: | 9 |
開始ページ: | 1384 |
終了ページ: | 1392 |
抄録: | The synthesis of benzocyclobutenes from simple arenes bearing a directing group was investigated via the palladium-catalyzed cyclization of norbornene derivatives. This approach allowed for the facile construction of benzocyclobutenes along with the double functionalization of the C - H bonds at the positions ortho and meta to the directing group. This result shows that the key palladacyclopentene intermediate in the Catellani reaction can be prepared by the directed double ortho C - H activation of the substrate. The results of this study also revealed that the combination of an N-protected amino acid with benzoquinone (BQ) was effective for this transformation. |
著作権等: | 許諾条件に基づいて掲載しています。 |
URI: | http://hdl.handle.net/2433/235953 |
DOI(出版社版): | 10.1248/cpb.c16-00439 |
PubMed ID: | 27581643 |
出現コレクション: | 学術雑誌掲載論文等 |
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