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ファイル | 記述 | サイズ | フォーマット | |
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j.jtbi.2019.04.008.pdf | 450.59 kB | Adobe PDF | 見る/開く |
タイトル: | Non-equilibrium thermodynamics of biological signal transduction predicts conservation of entropy production rate |
著者: | Tsuruyama, Tatsuaki |
著者名の別形: | 鶴山, 竜昭 |
キーワード: | Signal transduction Non-equilibrium linear thermodynamics Entropy production rate |
発行日: | 7-Jul-2019 |
出版者: | Academic Press |
誌名: | Journal of Theoretical Biology |
巻: | 472 |
開始ページ: | 84 |
終了ページ: | 87 |
抄録: | Studies have reported that bio-cellular signal transduction can be investigated based on thermodynamics. This short article aims to consider signal transduction carried out by signaling molecules from the perspective of non-equilibrium thermodynamics. Under conditions in which total entropy production rate was minimized, the entropy production rate per signaling molecule was conserved independently of the steps during signal transduction. Accordingly, the conserved production rate can be defined as the channel capacity of the given signal transduction cascade. Non- equilibrium thermodynamics provides a theoretical framework for cell signal transduction. |
著作権等: | © 2019 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
URI: | http://hdl.handle.net/2433/241544 |
DOI(出版社版): | 10.1016/j.jtbi.2019.04.008 |
PubMed ID: | 30978350 |
出現コレクション: | 学術雑誌掲載論文等 |
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