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Title: Non-equilibrium thermodynamics of biological signal transduction predicts conservation of entropy production rate
Authors: Tsuruyama, Tatsuaki
Author's alias: 鶴山, 竜昭
Keywords: Signal transduction
Non-equilibrium linear thermodynamics
Entropy production rate
Issue Date: 7-Jul-2019
Publisher: Academic Press
Journal title: Journal of Theoretical Biology
Volume: 472
Start page: 84
End page: 87
Abstract: Studies have reported that bio-cellular signal transduction can be investigated based on thermodynamics. This short article aims to consider signal transduction carried out by signaling molecules from the perspective of non-equilibrium thermodynamics. Under conditions in which total entropy production rate was minimized, the entropy production rate per signaling molecule was conserved independently of the steps during signal transduction. Accordingly, the conserved production rate can be defined as the channel capacity of the given signal transduction cascade. Non- equilibrium thermodynamics provides a theoretical framework for cell signal transduction.
Rights: © 2019 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license. (
DOI(Published Version): 10.1016/j.jtbi.2019.04.008
PubMed ID: 30978350
Appears in Collections:Journal Articles

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